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Gene regulatory network controlling neural crest derived formation of facial cartilage
Organization CALIFORNIA INSTITUTE OF TECHNOLOGYLocation PASADENA, UNITED STATESPosted 1 Jun 2014Deadline 31 Mar 2026 ⚠️
NIHUS FederalResearch GrantFY2025AddressAmazeAnteriorAssayBasal Transcription FactorBasal transcription factor genesBioassayBiological AssayBirth DefectsBisphosphonatesBone necrosisBranchial arch structureCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCUT&RUNCancersCartilageCartilaginous TissueCas nuclease technologyCell BodyCell Communication and SignalingCell DifferentiationCell Differentiation processCell SignalingCellsCephalicCharacteristicsChick EmbryoChondrocytesChromatinCleavage Targets and Release Using NucleaseCleavage Under Targets and Release Using NucleaseClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyComplexCongenital AbnormalityCongenital Anatomical AbnormalityCongenital DefectsCongenital DeformityCongenital MalformationCoupledCranialDevelopmentDrugsES cellEctopic ExpressionElectroporationEmbryoEmbryonicEndowmentEnhancersEnvironmentFaceFacial BonesGangliaGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic TranscriptionGenomic approachGliaGlial CellsGoalsGrantHeadHeartIn Situ HybridizationIntracellular Communication and SignalingKnock-outKnockoutKolliker's reticulumLinkMalignant MelanomaMalignant NeoplasmsMalignant TumorMediatingMedicationMelanomaMesodermMorphologyMultipotent Stem CellsNerve CellsNerve UnitNeural CellNeural CrestNeural Crest CellNeural GanglionNeuroblastomaNeurocyteNeurogliaNeuroglial CellsNeuronsNon-neuronal cellNonneuronal cellOsteonecrosisPathway interactionsPattern FormationPeripheralPeripheral Nervous SystemPharangeal ArchPharmaceutical PreparationsPopulationRNA ExpressionRegulatory ElementReporterResolutionSensory GangliaSeriesSignal TransductionSignal Transduction SystemsSignalingSignaling MoleculeSkeletonSkinSpecific qualifier valueSpecifiedTestingTimeTranscript Expression AnalysesTranscript Expression AnalysisTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTransplantationTransposaseValidationVisceral ArchesWorkanalyze gene expressionbiological signal transductionbiphosphonatebisphosphonatebonebranchial archcandidate identificationcell typecellular differentiationchicken embryocleft lip and palatecleft lip/palatecleft palate/lipcomparativecraniofacialcraniofaciesdevelopmentaldiphosphonatedrug/agentelectroporative deliveryembryo derived stem cellembryonal stem cellsembryonic progenitorembryonic stem cellface bone structurefacesfacialgene electrotransfergene expression analysisgene expression assaygene regulatory networkgenomic effortgenomic strategyin situ Hybridization Geneticsin situ Hybridization Staining Methodin vivoinsightlong bonemalignancymelanocytemigrationmultipotent progenitormultipotent progenitor cellneoplasm/cancernerve cementneural controlneural plateneural regulationneuromodulationneuromodulatoryneuronalneuroregulationossa facieipathwaypharyngeal archprogenitor cell poolprogenitor cell populationprogenitor poolprogenitor populationprogramspublic health relevanceresolutionsresponsescRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingskeletonsstem and progenitor cell populationstem cell of embryonic originstem cell poolstem cell populationtranscription factortranscriptional profilingtranscriptomicstransplanttumorvalidationsvertebrate embryos
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Description preview
In the previous grant period, we explored regulatory differences between cranial and trunk neural crest
cells. Comparative transcriptomics coupled with functional perturbation revealed a premigratory “cranial-specific”
neural crest GRN subcircuit that links anterior identity to ability to differentiate into facial cartilage. Here, we
propose to…
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