Ga-selective adenosine A1 receptor agonists as novel analgesics devoid of cardiorespiratory depression

Chronic pain, defined as continuous, frequent, or recurring pain lasting more than three months, affects up to 50% of the UK population. Such pain is often not adequately treated with available painkillers, and sufferers may end up having to take powerful drugs, such as opioids, which have undesirable and harmful side effects including nausea,…