grant
Functional role of Sec20, a BH3 and Secretory (Sec) domain protein, in neurons and its relevance to a motor neuron disease in Drosophila
Organization UNIVERSITY OF ALABAMA AT BIRMINGHAMLocation BIRMINGHAM, UNITED STATESPosted 15 Apr 2023Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY202621+ years oldAdenoviridaeAdenovirusesAdultAdult HumanAffectAmentiaAmyotrophic Lateral SclerosisAmyotrophic Lateral Sclerosis Motor Neuron DiseaseAmyotrophic lateral sclerosis and frontotemporal degenerationAmyotrophic lateral sclerosis and frontotemporal dementiaApoptosisApoptosis PathwayApoptoticAutophagocytosisAutophagosomeB cell lymphoma 2B-Cell CLL/Lymphoma 2 GeneB-cell lymphoma/leukemia-2BCL2BCL2 geneBCL2-Interacting ProteinBcl-2BioenergeticsBiologic ModelsBiological ModelsBiologyBrainBrain DiseasesBrain DisordersBrain Nervous SystemC9ORF72Cell DeathCessation of lifeChromosomesCitrate (si)-SynthaseCitrate SynthaseCollaborationsDNA Molecular BiologyDNA mutationDP5DataDeathDefectDegenerative Neurologic DisordersDementiaDevelopmentDiseaseDisorderDrosophilaDrosophila genusEncephalonEncephalon DiseasesErythrocupreinEyeEyeballFTD dementiaFTD/ALSFTLD/ALSFailureFemaleFliesFrontal Temporal DementiaFrontotemporal DementiaFrontotemporal Lobar Degeneration/Amyotrophic lateral sclerosisGWA studyGWASGehrig's DiseaseGenesGeneticGenetic ChangeGenetic ModelsGenetic defectGenetic mutationGlutamatesGoalsHRK geneHarakiriHealthHemocupreinHumanIntracranial CNS DisordersIntracranial Central Nervous System DisordersKnowledgeL-GlutamateLinkLou Gehrig DiseaseLysosomesMediatingMissionMitochondriaModel SystemModern ManMolecularMolecular BiologyMotor CellMotor Neuron DiseaseMotor NeuronsMovementMutationNational Institutes of HealthNerve CellsNerve UnitNervous SystemNervous System Degenerative DiseasesNervous System DiseasesNervous System DisorderNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeurobiologyNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Body SystemNeurologic Degenerative ConditionsNeurologic DisordersNeurologic Organ SystemNeurological DisordersNeurologyNeuronsORFsOpen Reading FramesOrthologOrthologous GenePathologyPatientsPeptide DomainPhenotypePlayProgrammed Cell DeathProtein Coding RegionProtein DomainsProtein FamilyProteinsPublic HealthPublishingReportingRisk FactorsRoleSamplingSuperoxide DismutaseSystemTechniquesTertiary Protein StructureUnited States National Institutes of HealthWorkadulthoodamyotrophic lateral sclerosis with frontotemporal dementiaamyotrophic lateral sclerosis/FTLDamyotrophic lateral sclerosis/frontotemporal dementiaamyotrophic lateral sclerosis/ftdapoptosis of neuronal cellsautophagybcl-2 Genesbody movementced9 homologcell transformationchromosome 9 open reading frame 72cytocupreindegenerative diseases of motor and sensory neuronsdegenerative disorder of motor neuronsdegenerative neurological diseasesdevelopmentalflyfront temporal dementiafrontal lobe dementiafrontotemporal dementia-amyotrophic lateral sclerosisfrontotemporal lobar degeneration dementiafrontotemporal lobar dementiafrontotemporal lobar dementia amyotrophic lateral sclerosisfrontotemporal lobe degeneration associated with dementiafruit flygene functiongenome mutationgenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studyglutamatergicinsightknock-downknockdownloss of functionmalemembermitochondrialmitochondrial dysfunctionmotoneuronmotor deficitmotor diseasemotor disordermotor dysfunctionmotor neuron functionmouse modelmurine modelmutantnecrocytosisnerve cell deathnerve cell lossneurobiologicalneurodegenerative illnessneurological diseaseneuron apoptosisneuron cell deathneuron cell lossneuron deathneuron lossneuronalneuronal apoptosisneuronal cell deathneuronal cell lossneuronal cells programmed cell deathneuronal deathneuronal lossneuronal survivalneurons programmed cell deathpreventpreventingpro-apoptotic proteinprogrammed cell death of neuronal cells by apoptosisprogrammed cell death of neurons by apoptosisrecruitsocial roletooltransformed cellswhole genome association analysiswhole genome association study♀♂
Description preview
This proposal examines the functional role of Sec20, a BH3 and Secretory (Sec) domain protein, in
neurons and its relevance to a motor neuron disease using Drosophila. It also examines the interaction
between sec20 and GGGGCC (G4C2) repeats of the gene C9orf72 (Chromosome9 open reading frame), a well-
known mutation that causes Amyotrophic Lateral…
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