grant

Functional characterization of adipocyte-derived lipocalin 2-containing extracellular vesicles in senescence

Organization UNIVERSITY OF MINNESOTALocation MINNEAPOLIS, UNITED STATESPosted 1 Feb 2026Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY2026ACRP30 proteinAdipocytesAdipose CellAdipose tissueAdult-Onset Diabetes MellitusAgingAutoregulationBinding ProteinsBlood NeutrophilBlood Polymorphonuclear NeutrophilBlood VesselsBody TissuesBrown Adipose TissueBrown FatCardiometabolic DiseaseCardiometabolic DisorderCell AgingCell BodyCell CommunicationCell InteractionCell IsolationCell SegregationCell SenescenceCell SeparationCell Separation TechnologyCell to Cell Communication and SignalingCell-Cell SignalingCell-to-Cell InteractionCellsCellular AgingCellular SenescenceCommunicationDefectDevelopmentDysfunctionExhibitsExposure toFat CellsFat progenitor cellFat stem cellFatty TissueFemaleFunctional disorderGrantHealthHeterogeneityHibernating GlandHigh Fat DietHomeostasisHumanHyperplasiaHyperplasticHypertrophyImpairmentInflammationInflammatoryKO miceKetosis-Resistant Diabetes MellitusKnock-out MiceKnockout MiceKnowledgeLCN2LCN2 geneLifeLigand Binding ProteinLigand Binding Protein GeneLinkLipidsLipocalin 2LipocytesMaintenanceMarrow NeutrophilMature LipocyteMature fat cellMaturity-Onset Diabetes MellitusMediatingMembraneMetabolicMetabolic DiseasesMetabolic DisorderMiceMice MammalsModern ManMurineMusNGALNIDDMNeutrophil Gelatinase-Associated LipocalinNeutrophilic GranulocyteNeutrophilic LeukocyteNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNull MouseObesityOncogenic Lipocalin 24P3OrganOutcomePathogenesisPhosphatidesPhosphatidic AcidPhospholipidsPhysiological HomeostasisPhysiopathologyPlayPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPrevalencePreventionProcessProgenitor CellsPropertyProtein BindingProteinsRegulationReplicative SenescenceRisk FactorsRoleSignaling MoleculeSlow-Onset Diabetes MellitusStable Diabetes MellitusStressT2 DMT2DT2DMTherapeuticThesaurismosisTissuesType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesUterocalinVisceraladipocyte complement-related protein 30-kDaadipocyte developmentadipocyte differentiationadipocyte progenitorsadipocyte stem celladipocyte, C1q and collagen domain containing proteinadipocyte-derived stem celladipocytokinesadipogenesisadipokinesadiponectinadiposeadipose derived stem celladipose progenitoradipose stem celladipose tissue derived stem celladipose tissue stem cellsadiposityadult onset diabetesage associated diseaseage associated disorderage associated impairmentage dependent diseaseage dependent disorderage dependent impairmentage related human diseaseage-related diseaseage-related disorderage-related impairmentagedaged miceaged mouseaging associatedaging relatedapM-1 proteinapM1 (adipose-specific) proteinbound proteincell sortingcombatcorpulencedevelopmentalelderly miceendocrine cellextracellularextracellular vesiclesfat derived stem cellinsightintercellular communicationketosis resistant diabeteslipid biosynthesislipogenesismaturity onset diabetesmembrane structuremetabolism disordermultipotencymultipotentneutrophilnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachobesity interventionobesity therapyobesity treatmentold micepathophysiologyrepairrepairedreplicative agingscRNA sequencingscRNA-seqselective expressionselectively expressedsenescencesenescentsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolestemstem cellsstromal progenitorstromal stem cellsubcutaneoussubdermaltype 2 DMtype II DMtype two diabetesuptakevascularwhite adipose tissueyellow adipose tissue♀
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PROJECT SUMMARY
Maintaining healthy adipose tissue function is essential for metabolic homeostasis and the prevention
of metabolic diseases. As potent endocrine cells, adipocytes secret various bioactive molecules and
extracellular vesicles that influence the function of tissues and organs throughout the body. Besides
adipocytes, multipotent stem…

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Functional characterization of adipocyte-derived lipocalin 2-containing extracellular vesicles in senescence — UNIVERSIT | Dev Procure