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Functional and molecular organization of lateral septum in threat processing

Organization HARVARD MEDICAL SCHOOLLocation BOSTON, UNITED STATESPosted 15 Mar 2024Deadline 2 Mar 2025 ⚠️
NIHUS FederalResearch GrantFY2025ACTH-Releasing FactorAffective DisordersAmmon HornAnatomic SitesAnatomic structuresAnatomyAnxiety DisordersArchitectureArousalAvoidance LearningBehaviorBehavioralBehavioral ParadigmBrainBrain Nervous SystemBrain regionCRF-41CRHCRH geneCalciumCell BodyCell Communication and SignalingCell SignalingCellsCodeCoding SystemCornu AmmonisCorticoliberinCorticotropin-Releasing FactorCorticotropin-Releasing Factor-41Corticotropin-Releasing HormoneCorticotropin-Releasing Hormone-41CuesDataDiseaseDisorderDoctor of PhilosophyDysfunctionEncephalonEngineering / ArchitectureEnvironmentExcitotoxic lesionFamilyFunctional disorderG Protein-Complex ReceptorG Protein-Coupled Receptor GenesG-Protein-Coupled ReceptorsGPCRGene TranscriptionGenetic TranscriptionGoalsHealthHeterogeneityHippocampusHumanHypothalamic structureHypothalamusImageIntracellular Communication and SignalingLaboratoriesLateralLearningLinkMapsMathMathematicsMediatingMental disordersMental health disordersMiceMice MammalsModern ManMolecularMolecular Dynamics SimulationMonitorMood DisordersMotivationMurineMusNerve CellsNerve UnitNeural CellNeurocyteNeuronsOpticsOutcomeOutputPTSDPh.D.PhDPhysiologicPhysiologicalPhysiopathologyPopulationPopulation ProcessPopulation-Level ProcessPositionPositioning AttributePost-Traumatic NeurosesPost-Traumatic Stress DisordersPosttraumatic NeurosesProcessPsychiatric DiseasePsychiatric DisorderPunishmentRNA ExpressionReceptor ProteinRoleSensorySignal TransductionSignal Transduction SystemsSignalingSingle-Nucleus SequencingStimulusStressStressful EventStructureSystemTestingTherapeuticTrainingTranscriptionViral GeneticsWorkavoidance behaviorbiological adaptation to stressbiological signal transductioncell typecorticotropin releasing hormoneexperimentexperimental researchexperimental studyexperimentsgenetic approachgenetic strategyhippocampalhypothalamicimagingin vivoinsightinterestmental illnessmolecular dynamicsneuralneural mechanismneurobiological mechanismneuromechanismneuronalneuropsychiatric diseaseneuropsychiatric disordernovelopticaloptogeneticspathophysiologyperceptual stimulusphysicochemical phenomena related to the sensespost-trauma stress disorderposttrauma stress disorderpsychiatric illnesspsychological disorderrapid detectionreaction; crisisreceptorrecruitresponsesNuc-Seqsensory stimulussingle nucleus RNA-sequencingsingle nucleus seqsingle-nucleus RNA-seqsnRNA sequencingsnRNA-seqsocial rolestress responsestress; reactionstressful experiencestressful life eventstressful life experiencetheoriestranscriptomicstraumatic neurosisvirus genetics

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PROJECT SUMMARY
The lateral septum (LS) is an inhibitory limbic brain structure long thought to be essential for threat processing
and defensive behavior. In part due to its anatomical and molecular heterogeneity, the precise means by which
the LS mediates these processes remains elusive. To this end, I have focused my graduate work on LS neurons…

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Functional and molecular organization of lateral septum in threat processing — HARVARD MEDICAL SCHOOL | UNITED STATES | | Dev Procure