grant
Functional and Mechanistic Studies of the Role of Lp17-encoded Factors in Host Adaptation by the Lyme Disease Spirochete
Organization WASHINGTON STATE UNIVERSITYLocation PULLMAN, UNITED STATESPosted 12 Jul 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY2025AffectAnimalsAreaB burgdorferiB. burgdorferiBand Shift Mobility AssayBandshift Mobility AssayBindingBody TissuesBorrelia burgdorferiBorrelia burgdorferi sensu strictoBorreliella burgdorferiChIP SequencingChIP-seqChIPseqChromosomesChronicClinicalDNADNA BindingDNA Binding InteractionDNA boundDataDeoxyribonucleic AcidDialysisDialysis procedureDown-RegulationElectrophoretic Mobility Shift AssayEnvironmentGene Action RegulationGene Copy NumberGene DosageGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGenerationsGenesGeneticGenetic TranscriptionGenomic SegmentGoalsHealthHeartHumanImpairmentIn VitroInfectionInflammationIntercistronic RegionIntergenic RegionsIxodidaJointsKnowledgeLife CycleLife Cycle StagesLong-term infectionLyme BorreliosisLyme DiseaseLyme Disease SpirocheteMaintenanceMammaliaMammalsMembraneMessenger RNAMethodsMissionMobility Shift AssayModern ManMolecular InteractionMutateMutation AnalysisNational Institutes of HealthNatureNorth AmericaOspC proteinOutcomeOuter surface protein CPathogenesisPeripheralPhenotypePlasmidsPlayPromoter RegionsPromotor RegionsProteinsPublic HealthPublishingQuantitative RTPCRQuantitative Reverse Transcriptase PCRRNA ExpressionResearchRoleSystemTestingTherapeuticTicksTissuesTranscriptTranscriptionUnited States National Institutes of HealthVector-borne diseaseVector-borne infectious diseaseVector-transmitted diseaseVector-transmitted infectious diseaseWorkchromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingchronic infectioncrosslinkdevelop a vaccinedevelop vaccinesdevelopment of a vaccinedialysis therapydisabilitydosageenzooticfunctional outcomesgel shift assaygenetic elementgenetic promoter elementgenetic promoter sequencegenome segmentgenomic regionhuman pathogenin vivoinnovateinnovationinnovativelife courselyme spirochetemRNAmembrane structuremutantnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetospCpathogenpersistent infectionpreventpreventingpromoter sequenceqRTPCRsocial rolevaccine developmentvector-borne illnessvectorborne diseasevectorborne illnessvectorborne infectious disease
Description preview
Summary
The ability of Borrelia burgdorferi to cause Lyme disease is highly dependent on its capacity to
establish a successful infection upon entering the mammalian host. Moreover, survival of the pathogen in
nature is completely dependent on its enzootic life cycle involving both a tick and reservoir host. The transition
between these two very…
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