grant
Function of Putative Determinant in Hematopoiesis
Organization ICAHN SCHOOL OF MEDICINE AT MOUNT SINAILocation NEW YORK, UNITED STATESPosted 1 Aug 1993Deadline 31 Jan 2031
NIHUS FederalResearch GrantFY2026APOEAbscissionActivator AppliancesActivator Orthodontic AppliancesAcuteAddressAffectAnemiaApo-EApoE proteinApolipoprotein EAssayBMACBRAKBasal Transcription FactorBasal transcription factor genesBindingBioassayBiochemicalBiologicalBiological AssayBiological FunctionBiological ProcessBiologyBolekineCCL3CCL3 geneCXCL14CXCL14 geneCell BodyCell DifferentiationCell Differentiation processCell LineCellLineCellsChemokine (C-C motif) Ligand 3Chemotactic CytokinesChromatinCollaborationsComplexCongenital dyserythropoietic anemiaConsultationsCultured CellsDNADNA mutationDeoxyribonucleic AcidDevelopmentDifferences of sex developmentDistalDysfunctionEKLFEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessErythroidErythroid CellsErythropoiesisEventExcisionExhibitsExtirpationFGF9FGF9 geneFunction ActivatorFunctional disorderFundingG0S19-1Gene Action RegulationGene ActivationGene Down-RegulationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGeneticGenetic ChangeGenetic ModelsGenetic TranscriptionGenetic defectGenetic mutationGenomicsGlobinHBFG-9HandHematopoiesisHematopoieticHematopoietic Cellular Control MechanismsHemoglobinHeterozygoteHigher Order Chromatin FoldingHigher Order Chromatin StructureHigher Order StructureHomologous Chemotactic CytokinesHumanHuman Cell LineIntercrinesInvestigationKS1KineticsLD78ALPHALeadLeftLettersLinkLongitudinal StudiesLongitudinal SurveysMGC10687MIP 1alphaMIP-1-alphaMIP-1aMIP-2gMIP1AMacrophageMetabolicMethodologyMiceMice MammalsModelingModern ManMolecularMolecular InteractionMouse StrainsMurineMusMutationMφNJACNuRDNuRD complexParentsPatientsPatternPb elementPhasePhysiopathologyPlayProcessPropertyProtein AnalysisProteinsProtocolProtocols documentationRNA ExpressionReagentRecoveryRegulator GenesRemovalRepressionRepressor ProteinsResearchRoleSCYA3SCYB14SIS cytokinesSiteSmall Inducible Cytokine A3Stem Cell InhibitorStrains Cell LinesStructureSurgical RemovalSystemTechnologyTestingTimeTranscriptionTranscription Factor Proto-OncogeneTranscription InitiationTranscription RepressionTranscription factor genesTranscriptional Regulatory ElementsVariantVariationWithdrawalbiologicblood cell formationcell typecellular differentiationchemoattractant cytokinechemokineco-repressorconsultationcorepressorcultured cell linecytokinedevelopmentaldisorder of sexual developmentepigeneticallyerythroid Kruppel-like factorerythroid developmentestablished cell lineexperimentexperimental researchexperimental studyexperimentsfallsgene co-repressorgene corepressorgene repressiongenetic approachgenetic co-repressorgenetic corepressorgenetic strategygenetic trans acting elementgenome mutationgonad developmentgonad formationhandsheavy metal Pbheavy metal leadhemopoieticheterozygosityiPSiPSCiPSCsimprovedin vivoinduced pluripotent cellinduced pluripotent stem cellinducible pluripotent cellinducible pluripotent stem cellinnovateinnovationinnovativelong-term studylongitudinal outcome studieslongitudinal research studymalemouse geneticsmutantnovelp-Globinparentpathophysiologyprenatalprogramsregulatory generepressor complexresectionsex development disordersocial roletrans acting elementtranscription factorunborn♂
Description preview
SUMMARY
Cell-restricted transcriptional modulators play critical roles in the process of selective gene
regulation during hematopoiesis. We have been investigating the molecular and biological function of
Erythroid Krüppel-like Factor (EKLF; KLF1). EKLF is a cell-restricted transcription factor that is a global
regulator of genes essential for…
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