grant
Function and Regulation of ALDH1A1-positive Nigrostriatal Dopaminergic Neurons in Motor Performance and Parkinson's disease
Organization NATIONAL INSTITUTE ON AGINGLocation UNITED STATES
NIHUS FederalResearch GrantFY20254-Aminobutanoic Acid4-Aminobutyric Acid4-amino-butanoic acidAccelerationAminalonAminaloneAxonAxon TerminalsBaclofen ReceptorsBehavioralBindingBrainBrain Nervous SystemCalciumCell Communication and SignalingCell SignalingChloride ChannelsChloride Ion ChannelsCorpus StriatumCorpus striatum structureCoupledCrossbreedingCuesDA NeuronDREADDsDevelopmentDopamineDopamine neuronDorsalEncephalonExhibitsFiberGABAGABA-B ReceptorGRIN1GeneticGenetic HybridizationGluN1GlutamatesGoalsHydroxytyramineImageImpairmentImplantIntracellular Communication and SignalingL-GlutamateLabelLearningLightLocomotionLoxP-flanked alleleMapsMediatingMiceMice MammalsMolecularMolecular InteractionMotorMovementMurineMusN-methyl-D-aspartate receptor subunit NR1NMDA receptor A1NMDAR1NMDARA1 proteinNerve CellsNerve DegenerationNerve UnitNeural CellNeurocyteNeuron DegenerationNeuronsParalysis AgitansParkinsonParkinson DiseasePerformancePhotometryPhotoradiationPopulationPositionPositioning AttributePresynaptic Nerve EndingsPresynaptic TerminalsPrimary ParkinsonismPropertyReceptor ProteinRegulationRewardsSensorySignal TransductionSignal Transduction SystemsSignalingSliceStriate BodyStriatumSynaptic BoutonsSynaptic TerminalsTask PerformancesTimeViral VectorWhole-Cell RecordingsWorkbiological signal transductionbody movementdefined contributiondesigner receptors exclusively activated by designer drugsdevelopmentaldopaminergic neuronfloxedfloxed allelefunctional restorationgamma-Aminobutyric Acidgenetic approachgenetic strategyglutamate receptor, ionotropic, N-methyl D-aspartate 1glutamatergicimagingin vivoinsightlight gatedlocomotor learningmitochondrial dysfunctionmotor controlmotor learningmotor skill learningmouse modelmurine modelneural controlneural degenerationneural regulationneurodegenerationneurodegenerativeneurological degenerationneuromodulationneuromodulatoryneuronalneuronal degenerationneuronal excitabilityneuroprotectionneuroprotectiveneuroregulationoptical fiberoptogeneticsperceptual motor learningpreservationpresynapticreceptorresponserestore functionrestore functionalityrestore lost functionspatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial integrationspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsstriataltreadmillγ-Aminobutyric Acid
Description preview
To investigate the activity and regulation of ALDH1A1-positive nigrostriatal dopaminergic neurons (DANs) during motor control and motor skill learning, we will use fiber photometry to record dopamine release and presynaptic calcium transients from Aldh1a1+ DAN axon terminals in the dorsal striatum during open-field, treadmill, and rotarod tasks.…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click