grant
Fringe regulation of Notch signaling in osteoclasts
Organization EASTERN WASHINGTON UNIVERSITYLocation CHENEY, UNITED STATESPosted 1 Aug 2024Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025AquadiolArchitectureAutoimmune DiseasesBone DensityBone MatrixBone MetastasisBone Mineral DensityBone ResorptionBone cancer metastaticBone remodelingBony metastasisCatalogingCell BodyCell Communication and SignalingCell SignalingCellsChemosensitizationChemosensitization/PotentiationDeoxygalactoseDevelopmentDimenformonDiogynDiogynetsDiseaseDisorderEC 2.4EGFEGF geneEngineering / ArchitectureEnzyme GeneEnzymesEstraceEstradiolEstradiol-17 betaEstradiol-17betaEstraldineExhibitsExternal DomainExtracellular DomainFailureFamilyFractureFringe, Drosophila, Homolog of, ManicFucoseFucosyltransferase 1FutureGalactoside 2-alpha-L-fucosyltransferase 1Gene ExpressionGene TranscriptionGenetic TranscriptionGiant CellsGlycoside TransferasesGoalsHigh-Throughput RNA SequencingIndividualInfectionInflammationInflammatoryIntracellular Communication and SignalingKnowledgeLigandsMFNGMFNG geneManic FringeMeasurementMediatingMetabolic GlycosylationMetastasis to boneMetastatic Cancer to the BoneMetastatic Neoplasm to the BoneMetastatic Tumor to the BoneMetastatic malignant neoplasm to boneMethodsMiceMice MammalsMicroscopicModelingMorphologyMultinucleated Giant CellsMurineMusNotch Signaling PathwayOsseous metastasisOsteoclastic Bone LossOsteoclastsOsteolysisOvocyclinOvocylinPathway interactionsPatternPhysiologyPolykaryocytesPositionPositioning AttributePost-MenopausePost-menopausal PeriodPostmenopausal PeriodPostmenopausePotentiationProcessProgynonProteinsProteolysis and Signaling Pathway of NotchRNA ExpressionReceptor ActivationReceptor ProteinReceptor SignalingRegulationResistanceRetroviridaeRetrovirusesRiskRoleSecondary cancer of boneSecondary malignancy of boneSecondary malignant neoplasm of boneSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSkeletal metastasisSyncytiumSystemTestingTherapeuticTherapeutic EstradiolTranscriptionTransferaseTransferase GeneTzanck CellVirus-RetrovirusWorkafter menopausealpha-Fucoseautoimmune conditionautoimmune disorderautoimmunity diseasebiological signal transductionbonebone fracturebone lossbone loss preventionbone neoplasm secondarybone preservationcombinatorialdevelopmentalexperienceexperimentexperimental researchexperimental studyexperimentsfng gene productfollowing menopausefringe gene productfringe proteinglycosylationglycosyltransferasehealingimprovedknock-downknockdownlife spanlifespanmembermineralizationmouse modelmurine modelnew approachesnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generationnext generation therapeuticsnotchnotch proteinnotch receptorsnovel approachesnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel strategiesnovel strategynovel therapeuticsnovel therapyosteoclastogenesisoverexpressoverexpressionpast menopausepathwaypost-menopausalpostmenopausalpostmenopausal statusprevent bone lossreceptorrecruitrepairrepairedresistantresponseskeletalsocial rolesugartherapeutic candidatetherapeutic target
Description preview
Project Summary/Abstract
Notch signaling both positively and negatively regulates differentiation and function of
osteoclasts, and signaling through the different Notch receptors is modulated through
glycosylation first by Protein O-fucosyltransferase 1 (POFUT1) and then by members of the
Fringe family of N-acetylglucosaminyl transferases.…
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