grant
Fluorescence image guided surgery, adjuvant PDT, and the immune response
Organization CASE WESTERN RESERVE UNIVERSITYLocation CLEVELAND, UNITED STATESPosted 1 Jul 2024Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2026AblationAbscissionActive OxygenAddressAdjuvantAmerican maleAmerican manAmerican menAnimalsAntigen ReceptorsAntigen TargetingBiochemicalBiodistributionBiological MarkersBody TissuesC57BL/6 MouseCancer CauseCancer EtiologyCancer PatientCancerousCancersCanine SpeciesCanis familiarisCell BodyCellsCessation of lifeChemotherapy and RadiationChemotherapy and/or radiationClinicalClinical TreatmentClinical TrialsCutaneous DisorderDeathDermatosesDevelopmentDiagnosisDiseaseDisorderDogsDogs MammalsDoseDrug KineticsDrugsEnergy TransferExcisionExtirpationFOLHFOLH1FOLH1 geneFailureFeedbackFluorescenceFolate Hydrolase 1FoundationsFutureGCP2GlandGlutamate Carboxypeptidase IIGoalsHistopathologyHumanImage-Guided SurgeryImmune MonitoringImmune RegulatorsImmune responseImmune systemImmunocompetentImmunologic MonitoringImmunologic StimulationImmunological MonitoringImmunological StimulationImmunomodulatorsImmunomonitoringImmunostimulationImpotenceIncontinenceInjectionsInstitutionInvadedLigandsLightMalignant CellMalignant NeoplasmsMalignant TumorMalignant neoplasm of prostateMalignant prostatic tumorMeasuresMedicationMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMetastatic/RecurrentMiceMice MammalsMicroscopicModelingModern ManMolecularMorbidityMovementMurineMusMuscleMuscle CellsMuscle TissueMyocytesN-Acetylated Alpha-Linked Acidic Dipeptidase 1NAALAD1NAALADase INeoplasm MetastasisNerveNerve CellsNerve UnitNerve-Sparing SurgeryNeural CellNeurocyteNeuronsNormal CellNormal TissueNormal tissue morphologyO elementO2 elementOperative ProceduresOperative Surgical ProceduresOxygenOxygen RadicalsPSMPSMAPUVAPUVA PhotochemotherapyPathologicPathologyPatientsPharmaceutical PreparationsPharmacokineticsPhotochemotherapyPhotodynamic TherapyPhotoradiationPhotosensitizersPhotosensitizing AgentsPhysiologyPostoperativePostoperative PeriodPro-OxidantsProceduresProgression-Free SurvivalsProstateProstate AblationProstate CAProstate CancerProstate DiseaseProstate GlandProstate NeoplasmsProstate TumorProstate malignancyProstate-Specific Membrane AntigenProstatectomyProstatic DiseasesProstatic GlandProstatic NeoplasiaProstatic NeoplasmsProstatovesiculectomyR-Series Research ProjectsR01 MechanismR01 ProgramRadiation therapyRadical ProstatectomyRadiotherapeuticsRadiotherapyReactive Oxygen SpeciesRecurrenceRecurrentRecurrent Malignant NeoplasmRecurrent Malignant TumorRecurrent NeoplasmRecurrent tumorRemovalReportingResearch GrantsResearch Project GrantsResearch ProjectsResectedSecondary NeoplasmSecondary TumorSkin DiseasesSkin Diseases and ManifestationsSurgeonSurgicalSurgical InterventionsSurgical ProcedureSurgical RemovalSurgical marginsSystemTechniquesTechnologyTestingTherapeuticTimeTissuesTransducersTreatment EfficacyTreatment outcomeU.S. MalesUS MenUS maleUnresectableUrologic SurgeonVisualizationWorkbio-markersbiologic markerbiomarkerbody movementcancer cellcancer metastasiscancer recurrencecaninecanine animal modelcanine modelchemo/radiation therapychemotherapy and radiotherapyclinical applicabilityclinical applicationclinical interventionclinical therapyclinical translationclinically translatablecutaneous diseasedermal diseasedermal disorderdevelopmentaldog modeldomestic dogdrug developmentdrug/agentefficacy trialfluorescence imagingfluorescence-guided surgeryfluorescent imaginghigh riskhost responseimaging probeimmune competentimmune modulatorsimmune system responseimmunomodulatory moleculesimmunoregulatorimmunoregulatory moleculesimmunoresponseimpotentimprovedinnovateinnovationinnovativeintervention efficacyintra-operative imagingintraoperative imagingirradiationmalemales in Americamales in the U.S.males in the USmales in the USAmales in the United Statesmalignancymen in Americamen in the U.S.men in the USmen in the USAmen in the United Statesminimally invasivemolecular imagingmolecule imagingmouse modelmurine modelmuscularneoplasm recurrenceneoplasm/cancerneoplasm/cancer photoradiation therapyneuronalnovelphotosensitizerpreventprevent relapsepreventingprostate cancer cellprostate cancer modelprostate cancer riskprostate disorderprostate tumor cellprostate tumor modelradiation or chemotherapyradiation treatmentrelapse preventionresectionresponse to therapyresponse to treatmentscreeningscreeningsserum PSAserum prostate specific antigenside effectskin disordersuccesssurgerysurgical imagingtargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttheranosticstherapeutic efficacytherapeutic responsetherapy efficacytherapy responsetreatment responsetreatment responsivenesstreatment with radiationtrial regimentrial treatmenttumortumor cell metastasistumor diagnosticuptake♂
Description preview
Abstract. Prostate cancer (PCa) is the most prevalent cancer among men in the United States and radical
prostatectomy remains one of the three treatment options for these patients. Screening with serum prostate specific antigen
(PSA) allows for 78% of prostate cancers to be diagnosed at the early localized stage, facilitating therapy with radical…
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