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Fibrotic remodeling of lymph nodes disrupts T cell function in fibrosis and cancer
Organization HARVARD UNIVERSITYLocation CAMBRIDGE, UNITED STATESPosted 1 Jan 2024Deadline 18 May 2025 β οΈ
NIHUS FederalResearch GrantFY2025AffectAnimal ModelAnimal Models and Related StudiesAntigen-Presenting CellsAntigensAreaAtomic Force MicroscopyAutoregulationBiochemicalBiologyBiomedical EngineeringBiophysicsBody TissuesCancer BiologyCancer CauseCancer EtiologyCancer PatientCancer Research ProgramsCancer Research ProjectCancersCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCell SurvivalCell ViabilityCell surfaceCell-Extracellular MatrixCellsCellular FunctionCellular MechanotransductionCellular PhysiologyCellular ProcessCellular biologyCessation of lifeChronicCicatrixClinicalCold-Insoluble GlobulinsCollagenCombined Modality TherapyComplementComplement ProteinsCuesDeathDepositDepositionDevelopmentDiseaseDisease ProgressionDisorderDoctor of PhilosophyDysfunctionECMEffectivenessEnsureExtracellular MatrixExtracellular Matrix ProteinsFN1FibroblastsFibronectin 1FibronectinsFibrosing AlveolitisFibrosisForce MicroscopyFunctional disorderFutureGenesGeneticGoalsHealthHomeostasisHumanImageImmuneImmune Cell ActivationImmune EvasionImmune infiltratesImmune mediated therapyImmunesImmunologically Directed TherapyImmunologyImmunotherapyIn VitroInjuryIntegrin aVBeta3Integrin alpha-v beta-3Integrin alphaVbeta3Integrin Ξ±VΞ²3IntegrinsIntegrins Extracellular MatrixIntracellular Communication and SignalingKnowledgeLETS ProteinsLarge External Transformation-Sensitive ProteinLearning SkillLinkLung Tissue FibrosisLymph Node Reticuloendothelial SystemLymph node properLymphatic cellLymphatic nodesLymphocyteLymphocyticMalignant MelanomaMalignant NeoplasmsMalignant TumorMalignant Tumor of the LungMalignant neoplasm of lungMeasuresMechanical Signal TransductionMechanicsMechanosensory TransductionMediatingMelanomaMelanoma TumorMelanoma patientMentorsMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMethodsMiceMice MammalsModern ManMultimodal TherapyMultimodal TreatmentMurineMusMyofibroblastNeoplasm MetastasisOncogenesisOpsonic GlycoproteinOpsonic alpha(2)SB GlycoproteinOrganOutcomePathogenicityPathologicPathologyPathway interactionsPh.D.PhDPhasePhenotypePhysiological HomeostasisPhysiopathologyPostdocPostdoctoral FellowProcessProductionPrognosisProliferatingPropertyPulmonary CancerPulmonary FibrosisPulmonary malignant NeoplasmR-Series Research ProjectsR01 MechanismR01 ProgramResearchResearch AssociateResearch GrantsResearch Project GrantsResearch ProjectsReticular CellScanning Force MicroscopyScarsSecondary NeoplasmSecondary TumorSeriesSignal TransductionSignal Transduction SystemsSignalingSiteStromal CellsStructureSubcellular ProcessSystemT cell infiltrationT cell regulationT cell responseT-Cell ActivationT-Cell DepletionT-Cell DevelopmentT-Cell OntogenyT-CellsT-LymphocyteT-Lymphocyte DevelopmentT-cell depletion therapyT-lymphocyte depletion therapyTestingTherapeuticTissuesTrainingTranscription ActivatorTranscription CoactivatorTranscription Factor CoactivatorTranscriptional Activator/CoactivatorTumor PromotionTumor growth in melanomaWorkWound RepairaVBeta3accessory cellactivate T cellsadaptive immune responsealpha 2-Surface Binding Glycoproteinalpha-v beta-3 Integrin Receptorsanti-cancer immunotherapyanticancer immunotherapybio-engineeredbio-engineersbioengineeringbiological engineeringbiological signal transductionbiophysical foundationbiophysical principlesbiophysical sciencescancer immunologycancer immunotherapycancer metastasiscancer microenvironmentcancer progressioncell biologycombination therapycombined modality treatmentcombined treatmentcomplementationcytokinedevelopmentaldiffuse interstitial pulmonary fibrosisdraining lymph nodeengineered immune systemfibrosis in the lunghealingidiopathic pulmonary fibrosisimagingimmune activationimmune cell infiltrateimmune engineeringimmune evasiveimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based cancer therapiesimmune-based therapiesimmune-based treatmentsimmuno therapyimmunoengineeringimmunogenimmunotherapy for cancerimmunotherapy of cancerinhibitorinjuriesinnovateinnovationinnovativeinterestinterstitiallung cancerlung fibrosislymph celllymph glandlymph node microenvironmentlymph nodeslymphnodesmalignancymechanicmechanicalmechanical cuemechanical forcemechanical signalmechanosensingmechanotransductionmelanoma cancer modelmelanoma modelmelanoma tumor modelmodel of animalmouse modelmulti-modal therapymulti-modal treatmentmurine modelneoplasm immunologyneoplasm progressionneoplasm/cancerneoplastic progressionpathogenpathophysiologypathwaypatients suffering from melanomapatients with melanomapharmacologicpost-docpost-doctoralpost-doctoral traineeprofessorprogramsregional lymph noderesearch associatesresponsescaffoldscaffoldingsenescencesenescentspatial multiomicsspatial omicsspatial tri-omicsthymus derived lymphocytetumortumor cell metastasistumor immunologytumor microenvironmenttumor progressiontumorigenesiswound healingwound recoverywound resolution
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Project Summary/Abstract
Fibrosis is a hallmark of cancer that promotes proliferation, metastasis, and immune evasion by altering the
tumor stroma which accounts for up to 90% of tumor mass. In fibrosis, pathogenic departure from homeostasis
results in the excessive deposition of extracellular matrix (ECM) by myofibroblasts, creating discreteβ¦
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