grant

Fatal Overdose Review Teams - Research to Enhance Surveillance Systems (FORTRESS)

Organization INDIANA UNIVERSITY INDIANAPOLISLocation INDIANAPOLIS, UNITED STATESPosted 30 Sept 2022Deadline 31 Aug 2027
NIHUS FederalResearch GrantFY20240-11 years oldAccidentsAddressAdherenceAffectAggregated DataApplication ContextAttitudeCenters for Disease ControlCenters for Disease Control and PreventionCenters for Disease Control and Prevention (U.S.)Cessation of lifeChargeChildChild YouthChildhoodChildren (0-21)CollectionCommunitiesCountyDataData AggregationData BanksDatabanksDeathDecision MakingDevelopmentDrug TherapyDrug usageDrugsEnsureEpidemicEventEvidence based treatmentFatality rateGoalsGuidelinesHEAL InitiativeHarm MinimizationHarm ReductionHealthHelping End Addiction Long-termHelping End Addiction LongtermHelping to End Addiction Long-termHelping to End Addiction LongtermHistoryImprisonmentIndianaIndividualInterventionIntervention StrategiesInterviewLegalLinkMedicationModelingNational Institutes of HealthOpiate AddictionOpiate DependenceOpiatesOpioidOutcomeOverdoseOverdose reductionPerformancePharmaceutical PreparationsPharmacotherapyPhasePhilosophyPilot ProjectsPolicy MakingPopulationPractice GuidelinesPreventative strategyPrevention strategyPreventive strategyProliferatingPublic HealthPublic Health PracticeQualifyingRandomizedRecommendationRecording of previous eventsResearchResearch DesignResearch ResourcesResourcesRisk FactorsRuralServicesSocial ServiceSocial WorkSourceSpeedStudy TypeSurvey InstrumentSurveysSystemTestingTimeTrainingTranslatingUnited States Centers for Disease ControlUnited States Centers for Disease Control and PreventionUnited States National Institutes of HealthVisualizationco-morbidco-morbiditycomorbiditycontextual factorsdashboarddata analytics dashboarddata dashboarddata depositorydata infrastructuredata repositorydata set repositorydataset repositorydesigndesigningdevelopmentaldrug treatmentdrug usedrug/agenteffectiveness outcomeeffectiveness-related outcomesemotional traumaevidence basehistoriesimplementation outcomesimplementation processimprovedincarceratedincarcerationinterventional strategykidsmembermortalitymultidisciplinarymultiple data sourcesneglectnon-medical opioid usenonmedical opioid useopiate misuseopiate use disorderopioid addictionopioid dependenceopioid dependentopioid misuseopioid use disorderoverdose deathoverdose fatalitiesoverdose preventionoverdose riskpediatricpilot studyprogramspsychostimulant use disorderrandomisationrandomizationrandomly assignedreduce overdosereduction in overdoseservice gapsocialstimulant use disorderstudy designsuccesssystems researchtime usetooltrial comparinguptakeusabilityuser centered designvisual dashboardvisualization dashboardweb based dashboardweb dashboardyoungster
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Full Description

This study is part of the NIH’s Helping to End Addiction Long-term (HEAL) initiative to speed scientific solutions for the overdose epidemic, including opioid and stimulant use disorders. The NIH HEAL Initiative bolsters research across NIH to address the national opioid public health crisis and improve treatment for opioid misuse and addiction.
This project seeks to address the overdose epidemic by working with overdose fatality review (OFR) teams. Current OFR practices rely on the case review model to make policy and programmatic recommendations. However, the continued rise in overdose rates and sheer number of preventable overdose deaths suggest a need to shift OFR teams away from case review and toward using timely population-level data to better inform their recommendations and actions. The goal of our proposed project, Fatal Overdose Review Teams – Research to Enhance Surveillance Systems (FORTRESS), is to improve standard OFR practices by equipping OFRs with a data dashboard built on real-time aggregate data, record-linked across multiple sources and presented in a way that helps identify and visualize common “overdose touchpoints,” or opportunities to deliver harm-reduction services or engage individuals at risk for overdose in evidence-based treatment. Aligning with the goals of the HEAL Data2Action Program, the FORTRESS research team will leverage available resources and expertise to help OFRs translate data to action. During the R61 Phase, the research team will strengthen established cross-sector partnerships with two state agencies, the Indiana Department of Health and the Indiana Management Performance Hub (MPH), which provide the necessary statewide data infrastructure to record-link population-level administrative data from multiple sources. MPH has also successfully developed publicly accessible data dashboards. The FORTRESS team will build on the early successes of MPH to ensure more timely collection of overdose event data and design the “Overdose Touchpoints Dashboard” (Aim 1). Our team will train OFR team members in Data-Driven Decision Making (DDDM) to effectively use the dashboard. The FORTRESS team also includes individuals involved in developing the CDC’s OFR best practice guidelines and a pilot study of OFR adherence to these guidelines, which will inform our team’s development of an “OFR Fidelity Tool” (Aim 2). This tool will be the first of its kind. For the R33 phase, we will conduct a cluster-randomized stepped-wedge trial comparing the impact of our intervention (dashboard + DDDM training) versus standard OFR practices on both implementation (Aim 3) and effectiveness outcomes (Aim 4). Implementation outcomes include implementation

process fidelity (Stages of Implementation Completion), staff acceptance of harm reduction philosophies (qualitative interviews), OFR fidelity to CDC best practices (FORTRESS OFR Fidelity Tool), and usability of the Overdose Touchpoint Dashboard, (Systems Usability Scale). A statewide OFR data repository serves as a rich source of data on effectiveness outcomes, including OFR team recommendation quality and local actions to implement recommended overdose prevention strategies. We will also survey OFR team members to assess changes in their attitudes toward evidence-based overdose prevention strategies. In sum, the FORTRESS team is uniquely qualified to help OFRs use more comprehensive, available data to inform quality, action-oriented recommendations to reduce overdose.

Grant Number: 4R33DA057660-02
NIH Institute/Center: NIH

Principal Investigator: Matthew Aalsma

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