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Extracellular microRNA-mediated intercellular communication between retinal microglia and RPE
Organization UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTRLocation OKLAHOMA CITY, UNITED STATESPosted 30 Sept 2024Deadline 30 Apr 2026 β οΈ
NIHUS FederalResearch GrantFY2025Age related macular degenerationAge-Related MaculopathyAgingAlgorithmsBindingBiogenesisBody TissuesCNS Nervous SystemCell BodyCell Communication and SignalingCell SignalingCell to Cell Communication and SignalingCell-Cell SignalingCellsCentral Nervous SystemChronicComputer ModelsComputerized ModelsConditioned Culture MediaConditioned MediumDataData SetDevelopmentDiabetic RetinopathyDiseaseDisorderDown-RegulationElderlyEngineeringEyeEye diseasesEyeballFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFunctional RNAFutureGene Down-RegulationGene ExpressionGenesGoalsHortega cellHumanHuman EngineeringImageImmuneImmune responseImmunesImmunofluorescenceImmunofluorescence ImmunologicImpairmentInflammationInjectionsInjuryIntervention StrategiesIntracellular Communication and SignalingKO miceKnock-out MiceKnockout MiceLigandsLipidsLiteratureMachine LearningMeasuresMediatingMessenger RNAMiceMice MammalsMicroRNAsMicrogliaModelingModern ManModificationMolecular InteractionMurineMusNeural RetinaNeuraxisNoncoding RNANontranslated RNANull MouseOligoOligonucleotidesOrigin of LifeOuter pigmented layer of retinaPathologicPathologyPigment cell layer of retinaPigmented layer of retinaPopulation HeterogeneityPost-Transcriptional ControlPost-Transcriptional RegulationProteinsPublishingRNA DegradationRNA SeqRNA sequencingRNAseqReceptor ProteinRejuvenationRetinaRetina ProperRetinal DiseasesRetinal DisorderRetinal Pigment EpitheliumRetinal pigment epithelial cellsRoleSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSmall RNAStressStructureStructure of retinal pigment epitheliumSupporting CellTGF-Beta Type II ReceptorTGFBR2TGFBR2 geneTestingTherapeuticTissuesTrainingTranscription RepressionTransforming Growth FactorsTranslational InhibitionTranslational RepressionTranslationsTumor Growth FactorsUntranslated RNAWild Type Mouseadvanced ageage associatedage correlatedage dependentage dependent macular degenerationage induced macular degenerationage linkedage relatedage related macular diseaseage related macular dystrophyage specificaged miceaged mouseautoimmune uveitisbiological signal transductioncell typecofactorcomputational modelingcomputational modelscomputer based modelscomputerized modelingdevelopmentaldisease modeldisorder modeldiverse populationselderly miceexosomeexperimentexperimental researchexperimental studyexperimentsextracellularextracellular vesicleseye disorderfat metabolismflow cytophotometrygene functiongene repressiongeriatricgitter cellheterogeneous populationhiPSChost responsehuman iPShuman iPSChuman induced pluripotent cellhuman induced pluripotent stem cellshuman inducible pluripotent stem cellshuman inducible stem cellsimagingimmune system responseimmunoresponseimprovedin vivoinduced human pluripotent stem cellsinherited retinal degenerationinjuriesinsightintercellular communicationlipid metabolismmRNAmachine based learningmesogliamiR therapymiR-based therapeuticmiR-based therapymiRNAmiRNA deliverymiRNA therapymiRNA-based therapeuticmiRNA-based therapymicroRNA deliverymicroRNA therapymicroRNA-based therapeuticmicroRNA-based therapymicroglial cellmicrogliocytenoncodingocular diseaseocular disorderold miceoligosophthalmopathyox-LDLoxidized LDLoxidized low density lipoproteinperivascular glial cellpopulation diversitypost-transcriptional gene regulationprogramsprotective effectreceptorrelease factorresponseretina diseaseretina disorderretina ischemiaretinal ischemiaretinopathyscRNA sequencingscRNA-seqsenile macular diseasesenior citizenside effectsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial roletherapeutic miRNAtherapeutic miRstherapeutic microRNAtranscriptome sequencingtranscriptomic sequencingtransforming growth factor-beta type II receptortransforming growth factor-Ξ² type II receptortransforming growth factors Animal growth regulatorstranslationuptakevesicle releasevesicular releasewildtype mouse
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Description preview
The primary goals of this project are to investigate the transfer of extracellular microRNAs (miRNA) between
retinal pigment epithelium (RPE) and microglia as a means of intercellular communication and to evaluate the
use of engineered RPE-derived extracellular vesicles (EVs) as an interventional strategy to mitigate retinal
inflammation andβ¦
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