grant
Exploring the role of Lytic Polysaccharide Monooxygenase in Virulence and Immunity of Pseudomonasaeruginosa
Organization UNIVERSITY OF CALIFORNIA, SAN DIEGOLocation LA JOLLA, UNITED STATESPosted 1 Feb 2026Deadline 31 Jan 2031
NIHUS FederalResearch GrantFY20267S Gamma GlobulinActive ImmunizationActive vaccinationAddressAffinityAnimalsAntibiotic AgentsAntibiotic DrugsAntibioticsAntibody ResponseAntibody titer measurementAntigensBacteria resistanceBacteria resistantBacterial InfectionsBacterial resistantBindingBinding ProteinsBiochemicalBiomassBloodBlood NeutrophilBlood Polymorphonuclear NeutrophilBlood Reticuloendothelial SystemC 5b-9C5b-9CF lung diseaseCarbohydratesCell BodyCell LineCell-Extracellular MatrixCellLineCellsCelluloseChitinClinical Treatment MoabCommunicable DiseasesCommunicationComplementComplement Complex C5b-9Complement Membrane Attack ComplexComplement ProteinsCopperCu elementCytolytic Terminal Complement ComplexDataDrug KineticsECMENaCEffectivenessEngineeringEnzyme GeneEnzymesEpitope MappingEvaluationExtracellular MatrixFamilyGene ModifiedGenesGlycansGlycoproteinsGlycosaminoglycansGram-Negative BacteriaHemi-MyeloperoxidaseHeparan SulfateHeparitin SulfateHomology ModelingHospitalsHumanHydroxylasesIgGImmuneImmune EvasionImmunesImmunityImmunizeImmunocompetentImmunocompromisedImmunocompromised HostImmunocompromised PatientImmunoglobulin GImmunosuppressed HostIn VitroIndividualIndustrializationInfectionInfectious DiseasesInfectious DisorderInnate ImmunityKineticsKnowledgeLabelLibrariesLigand Binding ProteinLigand Binding Protein GeneLigandsLinkLungLung Respiratory SystemLung infectionsLyticMDR organismMDR pathogenMapsMarrow NeutrophilMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMedicalMembraneMembrane Attack ComplexMiceMice MammalsMiscellaneous AntibioticMixed Function OxidasesMixed Function OxygenasesModelingModern ManMolecularMolecular Dynamics SimulationMolecular InteractionMonoclonal AntibodiesMonooxygenasesMucopolysaccharidesMurineMusMyeloperoxidaseNative ImmunityNatural ImmunityNatureNeutrophilic GranulocyteNeutrophilic LeukocyteNon-Specific ImmunityNonspecific ImmunityNutritional ImmunityOrganoidsOxidasesOxidation-ReductionP aeruginosaP aeruginosa associated pneumoniaP aeruginosa caused pneumoniaP aeruginosa induced pneumoniaP aeruginosa pneumoniaP aeruginosa-associated pneumoniaP aeruginosa-caused pneumoniaP aeruginosa-induced pneumoniaP. aeruginosaP. aeruginosa associated pneumoniaP. aeruginosa caused pneumoniaP. aeruginosa induced pneumoniaP. aeruginosa infectionP. aeruginosa pneumoniaP. aeruginosa-associated pneumoniaP. aeruginosa-caused pneumoniaP. aeruginosa-induced pneumoniaPaperPassive ImmunizationPathogenesisPathogenicity FactorsPeroxidasesPharmacokineticsPhysiologyPneumoniaPolyanhydroglucuronic AcidPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPolysaccharidesPredispositionPreventative measurePreventive measureProphylactic treatmentProphylaxisProtein BindingProteinsProteoglycanProteomicsPseudomonas aeruginosaPseudomonas aeruginosa associated pneumoniaPseudomonas aeruginosa caused pneumoniaPseudomonas aeruginosa induced pneumoniaPseudomonas aeruginosa infectionPseudomonas aeruginosa pneumoniaPseudomonas pyocyaneaPublic HealthPublishingPulmonary Cystic FibrosisRecombinantsRedoxResearchResolutionRoentgen RaysRoleSepsisSingle Crystal DiffractionSpecificityStrains Cell LinesStructureSusceptibilitySystemic infectionTerminal Complement ComplexTherapeuticTherapeutic UsesTransgenic MiceVariantVariationVirulenceVirulence FactorsWorkX Ray CrystallographiesX-RadiationX-Ray CrystallographyX-Ray Diffraction CrystallographyX-Ray RadiationX-Ray/Neutron CrystallographyX-rayXrayXray Crystallographyalpha-Celluloseantibody titeringascorbateassess effectivenessbacteria infectionbacterial diseasebacterial resistancebiophysical approachesbiophysical methodologybiophysical methodsbiophysical techniquesbound proteincomplementationcultured cell linecystic fibrosis lungcystic fibrosis lung diseasedetermine effectivenessdisease modeldisorder modeleffectiveness assessmenteffectiveness evaluationepithelial Na+ channelepithelial sodium channelevaluate effectivenessexamine effectivenessflexibilityflexiblegene modificationgenetically modifiedhuman pathogenimmune competentimmune evasiveimmune response to vaccinationimmune response to vaccinesimmunogenimmunogenicimmunogenicityimmunosuppressed patientinfected with P. aeruginosainfected with Pseudomonas aeruginosainnate immune mechanismsinnovateinnovationinnovativemAbsmembrane structuremolecular dynamicsmonoclonal Absmonomermouse modelmulti-drug resistant organismmulti-drug resistant pathogenmultidrug resistant organismmultidrug resistant pathogenmultiple drug resistant organismmultiple drug resistant pathogenmurine modelmutantneutrophilnoveloxidation reduction reactionpassive vaccinationpathogenprogramsprophylacticpulmonary infectionsresistance to Bacteriaresistance to Bacterialresistant to Bacteriaresistant to Bacterialresolutionssocial rolestructural mutationstructural variantstructural variationvaccine associated immune responsevaccine immune responsevaccine immunogenicityvaccine induced immune response
Description preview
SUMMARY
Lytic polysaccharide monooxygenases (LPMOs) are crucial enzymes for breaking down tough polysaccharides
such as chitin and cellulose. Their discovery in 2010 revolutionized biomass conversion research due to their
industrial applications. However, the potential role of LPMOs in bacterial infectious diseases remains
underexplored. Several…
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