grant
Exploring the role of hippocampal hypervascularization in Rett syndrome pathogenesis
Organization BAYLOR COLLEGE OF MEDICINELocation HOUSTON, UNITED STATESPosted 1 Sept 2025Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY20252-photonAffectAmmon HornAngiogenesis InhibitionAngiogenesis PromoterAngiogenic InhibitionAnimalsAntibodiesArterial ObstructionArterial OcclusionArtery ObstructionBiologic ModelsBiologicalBiological ModelsBirthBlood - brain barrier anatomyBlood VesselsBlood-Brain BarrierBody TissuesBrainBrain Nervous SystemCell BodyCell Communication and SignalingCell SignalingCellsCerebroatrophic HyperammonemiaChronicCommon Rat StrainsConvulsantsCornu AmmonisCoupledDNA mutationDevelopmentDiseaseDisorderDrugsDysfunctionEEGElectroencephalogramElectroencephalographyElectrophysiologyElectrophysiology (science)EncephalonEndotheliumEpilepsyEpileptic SeizuresEpilepticsEpileptogenesisFLK1FemaleFunctional disorderGeneralized GrowthGenesGenetic ChangeGenetic DiseasesGenetic defectGenetic mutationGrowthHealthHemato-Encephalic BarrierHippocampusHistologicHistologicallyHumanHypoxiaHypoxicImageIndividualInfarctionInjuryIntracellular Communication and SignalingIntractable EpilepsyKDR geneMeCP-2 proteinMeCP2MeCP2 proteinMeasuresMediatingMedicationMethodsMethyl CpG binding protein MeCP2Methyl-CpG-Binding Protein 2Methyl-DNA binding protein MECP2MiceMice MammalsModel SystemModelingModern ManMolecularMonitorMurineMusMutationNerve CellsNerve UnitNervous System DiseasesNervous System DisorderNeural CellNeurocyteNeurologicNeurologic DisordersNeurologicalNeurological DisordersNeuronsNeurophysiology - biologic functionNeurophysiology / ElectrophysiologyNutrientOxygen DeficiencyParturitionPathogenesisPathologicPathologyPatientsPharmaceutical PreparationsPhenotypePhysiopathologyPilocarpineProtein AnalysisRatRats MammalsRattusRefractory epilepsyResistanceRett DisorderRett SyndromeRodent ModelRoleSeizure DisorderSeverity of illnessSignal TransductionSignal Transduction SystemsSignalingStressTemporal Lobe EpilepsyTestingTissue GrowthTissuesVEGFVEGF ReceptorsVEGFRVEGFR-2VEGFR2VEGFsVPF ReceptorVascular Endothelial Cell Growth Factor ReceptorVascular Endothelial Growth Factor Receptor 2Vascular Endothelial Growth FactorsVascular Permeability Factor ReceptorVascularizationWaste ProductsWorkangiogenesisartery occlusionbiologicbiological signal transductionbloodbrain barriercerebral arterydensitydevelopmentaldifferential expressiondifferentially expresseddisease modeldisease severitydisorder modeldrug-resistant epilepsydrug/agentelectrophysiologicalepilepsiaepileptogenicexperienceexperimentexperimental researchexperimental studyexperimentsgenetic conditiongenetic disordergenome mutationhippocampalimagingimaging studyinfarctinhibitorinjuriesinjury responseinsightknock-downknockdownmouse modelmurine modelneural functionneurological diseaseneuronalontogenypathophysiologypharmacologicpreservationresistantresponseresponse to injuryshRNAshort hairpin RNAsmall hairpin RNAsocial roletranscriptional differencestranscriptomicstwo-photonvascularvascular abnormality♀
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Rett syndrome is a severe neurological disorder caused by mutations in the MECP2 gene, affecting approximately 1 in 10,000 female births. About 70% of individuals with Rett syndrome experience epileptic seizures and nearly one-third of these cases are resistant to treatment, posing a substantial burden for patients. In my recent experiments, I…
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