grant
Exploring palmitoylation dynamics: impacts on Cadherin-Catenin adhesion and lipid metabolism in the progression of melanoma lung metastasis
Organization CLEVELAND CLINIC LERNER COM-CWRULocation CLEVELAND, UNITED STATESPosted 1 Sept 2025Deadline 31 Aug 2030
NIHUS FederalResearch GrantFY2025AdhesionsAffectB-raf-1BRAFBRAF geneBehaviorCadherin-1CadherinsCancer CauseCancer EtiologyCell AdhesionCell BodyCell CommunicationCell Communication and SignalingCell InteractionCell SignalingCell to Cell Communication and SignalingCell-Cell SignalingCell-to-Cell InteractionCellsCellular AdhesionCessation of lifeDataDeathDevelopmentDiagnosticE-CadherinEnzyme GeneEnzymesEpithelial Calcium-Dependent Adhesion ProteinEpithelial-CadherinFASNFASN geneHydrophobicityImmuneImmune EvasionImmune TargetingImmune responseImmunesImmunocompetentImmunomodulationIntracellular Communication and SignalingLipidsLungLung Respiratory SystemLysolecithinsLysophosphatidylcholinesMGC14367MGC15706MME geneMMP12MacrophageMalignant CellMalignant MelanomaMediatingMelanomaMelanoma CellMelanoma MetastasisMembraneMetabolicMetastasisMetastasis SuppressionMetastasis to the LungMetastasizeMetastatic LesionMetastatic MassMetastatic MelanomaMetastatic NeoplasmMetastatic Neoplasm to the LungMetastatic TumorMetastatic Tumor to the LungMiceMice MammalsModificationMolecularMurineMusMutateMφNF-1NF-1 ProteinNF-1 encoded proteinNF1NF1 GRPNF1 ProteinNF1 geneNF1 mutationNF1-GAP-Related ProteinNeoplasm MetastasisNeurofibromatosis 1 GenesNeurofibromatosis Type 1 Gene ProductNeurofibromatosis Type 1 ProteinNeurofibrominNeurofibromin 1OA-519OrganPD-1 blockadePD1 blockadePathway interactionsPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPhenotypePost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingProtein ModificationProteinsRAFB1RegulationResearchResistanceRoleSecondary NeoplasmSecondary TumorShapesSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSpecificitySurvival RateTherapeuticTumor Suppressor ProteinsTumor-associated macrophagesUvomorulinanti-PD-1 blockadeanti-PD1 blockadeanti-tumor immune responsebehavior responsebehavioral responsebiological signal transductioncancer cellcancer metastasiscancer microenvironmentdesigndesigningdevelopmentaleffective therapyeffective treatmentfat metabolismhost responsehuman diseaseimmune check pointimmune checkpointimmune competentimmune evasiveimmune microenvironmentimmune modulationimmune regulationimmune system responseimmunecheckpointimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimmunoresponseimmunosuppressive microenvironmentimmunosuppressive tumor microenvironmentimprovedinhibitorinsightintercellular communicationlipid metabolismlung metastasismacrophage metalloelastasemacrophage-specific metalloelastasematrix metalloproteinase 12membrane structuremetastasize to the lungneurofibromatosis type 1 geneneurofibromatosis type 1 protein/genenew approachesnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynf 1 Genesnovel approachesnovel strategiesnovel strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpalmitoylationpathwaypatient oriented outcomesprotein complexpulmonary metastasisresistantsocial rolesynergismtherapeutic targettreatment strategytumortumor cell metastasistumor growthtumor immune microenvironmenttumor microenvironmenttumor suppressortumor-immune system interactionsv-raf Murine Sarcoma Viral Oncogene Homolog B1
Description preview
Melanoma, a major cause of cancer deaths, often metastasizes to the lungs and other organs, leading to a low
five-year survival rate of 15-20% in advanced stages. The effective treatment of metastatic melanoma, including
in the lungs, remains a significant challenge. Therefore, research focusing on understanding and combating
pulmonary metastasis…
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