grant
Exploring Cholinergic Changes and their Associations with Sleep Alterations in the Lewy Body Disease Spectrum: New Biomarkers and Therapeutic Targets
Organization UNIVERSITY OF MICHIGAN AT ANN ARBORLocation ANN ARBOR, UNITED STATESPosted 16 Feb 2026Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY2026AcetylcholineActive Follow-upAffectAnimal ModelAnimal Models and Related StudiesAnimalsAreaBindingBiological MarkersBrainBrain Nervous SystemBrain StemBrain imagingBrainstemChemicalsClinicalDLBDataDegenerative Neurologic DisordersDementia with Lewy BodiesDevicesDiagnosisDiseaseDisorderDown-RegulationDrowsinessDysfunctionEncephalonExcessive Daytime SleepinessExcessive daytime somnolenceFast-Wave SleepFriendsFunctional disorderGenerationsGoalsHomeHumanImaging ProceduresImaging TechnicsImaging TechniquesIndividualInvestigationLB diseaseLB disorderLewy Body DiseaseLewy Body spectrum diseasesLewy Body spectrum disordersLewy body disorderLewy diseaseLewy disorderLinkMeasuresMethodsModelingModern ManMolecularMolecular InteractionMonitorNREMNerve DegenerationNerve Impulse TransmissionNerve TransmissionNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurobiologyNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeuron DegenerationNeuronal TransmissionPETPET ScanPET imagingPETSCANPETTParadoxical SleepParalysis AgitansParietal LobeParkinsonParkinson DiseasePatient Self-ReportPatientsPerformancePhasePhysiopathologyPlayPolysomnographyPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPrimary ParkinsonismQuestionnairesREM Behavior DisorderREM SleepREM Sleep Behavior DisorderRad.-PETRapid Eye Movement Behavior DisorderRapid Eye Movement Sleep Behavior DisorderReportingResearchRhombencephalic SleepRoleSelf-ReportSleepSleep ArchitectureSleep MonitoringSleep Wake CycleSleep disturbancesSomnographySomnolenceStructureSymptomsSynaptic VesiclesSystemTechnologyTestingTrainingTranslatingUpregulationVAChT proteinValidationaberrant sleepacetylcholine transporteractive followupaxon signalingaxon-glial signalingaxonal signalingbio-markersbiologic markerbiomarkerbrain healthbrain visualizationcholinergicclinical diagnosiscohortcomputer based predictiondegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdesigndesigningdisease diagnosisdisrupted sleepdisturbed sleepdreaming sleepfollow upfollow-upfollowed upfollowupfrontal cortexfrontal lobeglia signalingglial signalinghome based monitoringhome monitoringhomeshuman modelimpaired sleepimprovement on sleepin vivoinsightinterestirregular sleepmodel of animalmodel of humannerve signalingneural degenerationneural imagingneural signalingneuro-imagingneurobiologicalneurodegenerationneurodegenerativeneurodegenerative illnessneuroimagingneurological degenerationneurological imagingneuronal degenerationneuronal signalingneuroprotectionneuroprotectiveneurotransmissionnon rapid eye movementnon-REMnon-rapid eye movementnonREMnonrapid eye movementnovelparietal cortexpathophysiologypatient populationpositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypredictive modelingprogramsradiolabelradiolabelsradiotracerrapid eye movementrapid eye movement sleeprecruitskill acquisitionskill developmentsleep amountsleep controlsleep disruptionsleep durationsleep dysregulationsleep episodesleep improvementsleep intervalsleep lengthsleep measurementsleep patternsleep periodsleep polysomnographysleep quantitysleep regulationsleep routinesleep schedulesleep timesleep to wake transitionsleep to wakefulness transitionsleep wakefulness cyclesleep/wake disruptionsleep/wake disturbancesleep/wake patternssleep/wake regulationsleep/wake transitionssleepinesssocial roletherapeutic targettime asleeptime during sleeptime in sleeptime spent asleeptime spent sleepingtooltranslation to humanstranslational goaltranslational missionvalidationsvesicle releasevesicular acetylcholine transportervesicular releasewearablewearable devicewearable electronicswearable systemwearable technologywearable toolwearables
Description preview
Abstract
Cholinergic brain activity plays a crucial role in regulating sleep, particularly Rapid Eye Movement (REM) sleep,
as demonstrated in animal studies. How these findings translate to humans remains insufficiently explored.
Understanding the neurobiology of sleep in humans is critical, as sleep dysregulation is closely linked to…
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