grant

Explore efflux transporter-associated chemoresistance using a chemical biology approach and develop efflux resistant TOPO I inhibitors as ADC payloads

Organization UKRILocation United Kingdom
UKRIUK ResearchGrantActive
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Antibody-drug conjugates (ADCs) are an emerging class of cancer therapeutics that consist of a monoclonal antibody (mAb) connected to a cytotoxic drug via a linker. The antibody component determines the specificity of the ADC by binding to specific cell surface antigens, allowing selective targeting of certain cell types1. The main advantage of…

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Explore efflux transporter-associated chemoresistance using a chemical biology approach and develop efflux resistant TOP | Dev Procure