grant
Exploiting Carbon Monoxide Biofoams to Radio-Sensitize Rectal Cancer Cells While Protecting Normal Bowel
Organization UNIVERSITY OF IOWALocation IOWA CITY, UNITED STATESPosted 9 Jun 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025AbscissionAcuteAdjuvant TherapyAlimentary CanalAntioxidantsAntitumor ResponseBasal Transcription FactorBasal transcription factor genesBiochemicalBiocompatible MaterialsBiologyBiomaterialsBody TissuesCancer BiologyCancer PatientCancersCarbon MonoxideCatabolismCell BodyCell Communication and SignalingCell ProtectionCell RespirationCell SignalingCell SurvivalCell ViabilityCellsCellular RespirationCellular biologyChronicColorectal CancerCombination Drug TherapyCytoprotectionDNA Molecular BiologyDiagnosisDigestive TractDoseDoxycyclineEnvironmentEpithelial CellsEvaluationExcisionExposure toExtirpationFerroprotoporphyrinFormulationFree RadicalsGI TractGastrointestinal TractGastrointestinal tract structureGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGoalsH2O2HO-1 enzymeHO1HO2HSP32HemeHydrogen PeroxideHydroperoxideIn VitroIncidenceIndividualInduction TherapyInflammationInhalationInhalingInternationalIntestinalIntestinesIntracellular Communication and SignalingIowaKO miceKnock-out MiceKnockout MiceLeadMalignant CellMalignant NeoplasmsMalignant TumorMentorsMetabolicMethodologyMethodsMiceMice MammalsMitochondriaModelingMolecularMolecular BiologyMurineMusNEOADJNeoadjuvantNeoadjuvant TherapyNeoadjuvant TreatmentNormal CellNormal TissueNormal tissue morphologyNull MouseOperative ProceduresOperative Surgical ProceduresOrganism-Level ProcessOrganismal ProcessOxidation-ReductionOxidative StressOxidative Stress InductionPathologic ProcessesPathological ProcessesPathway interactionsPb elementPhysiciansPhysiologic ProcessesPhysiological ProcessesPolychemotherapyPositionPositioning AttributeProctitisProductionPropertyProtohemeQOLQOL improvementQuality of lifeQuantitative EvaluationsRadiationRadiation SensitivityRadiation ToleranceRadiosensitivityRadiosensitizationRectal CancerRectal CarcinomaRectumRedoxRegimenRemovalResearchRoleScientistSeverity of illnessSignal TransductionSignal Transduction SystemsSignalingStressSuperoxide AnionSuperoxide RadicalSuperoxidesSurgicalSurgical InterventionsSurgical ProcedureSurgical RemovalTestingTherapeuticTissuesTrainingTranscription Factor Proto-OncogeneTranscription factor genesTranslatingTranslationsTumor BurdenTumor CellTumor LoadTumor TissueUnited StatesUniversitiesVibramycinWorkadjuvant treatmentaerobic metabolismaerobic respirationalimentary tractalpha-6-Deoxyoxytetracyclineanti-canceranti-oxidant enzymeanti-tumor effectanti-tumor responseantioxidant enzymeantitumor effectbiological adaptation to stressbiological materialbiological signal transductionbiomaterial developmentbowelcancer cellcell biologycell killingchemo-/radio-sensitizationchemo-/radio-therapychemo-radiotherapychemoradiationchemoradiation therapychemoradiation treatmentchemoradiotherapycombination chemotherapycombination pharmacotherapycytoprotectivedigestive canaldisease severityenzyme pathwayferrohemegastrointestinalheavy metal Pbheavy metal leadheme oxygenase-1hemeoxygenase 1improvedimproved outcomeimprovements in QOLimprovements in quality of lifein vivoinduction therapiesinjury to tissueintestinal epitheliumirradiation responsemalignancymimeticsmitochondrialmouse modelmurine modelneoplasm/cancerneoplastic cellnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyoxidation reduction reactionoxidative damageoxidative injuryoxidative metabolismpathwaypharmacologicpreservationquality of life improvementradiation responseradiation sensitizationradio-/chemo-sensitizationradio-chemo-therapyradio-chemotherapyradio-sensitivityradio-sensitizationradiochemotherapyradiosensitiveradiotherapy sensitizationreaction; crisisrectitisrectum inflammationresectionresponseresponse to radiationskillssocial rolestress responsestress; reactionsurgerytissue injurytooltranscription factortranslationtranslational therapeuticstranslational therapy
Description preview
ABSTRACT
An estimated 45,230 individuals were diagnosed with rectal cancer in the United States in 2021. Rectal cancer
is primarily managed using a combination of chemotherapy, radiation, and surgery. Surgical resection of the
rectum is associated with long-term functional deficits and decreased quality-of-life. Therefore, strategies to
improve…
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