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Experimental model of depression in aging: anxiety, inflammation, and reward mechanisms
Organization UNIVERSITY OF CALIFORNIA LOS ANGELESLocation LOS ANGELES, UNITED STATESPosted 15 Mar 2022Deadline 4 Jan 2026 ⚠️
NIHUS FederalResearch GrantFY202521+ years oldAccelerationAcuteAddressAdultAdult HumanAdverse effectsAffectAffectiveAgeAgingAnxietyAutomobile DrivingBehaviorBehavioralBiologicalBiological MarkersBrainBrain Nervous SystemBrain regionChronic DiseaseChronic IllnessClinical TrialsCommunitiesCuesDataData AnalysesData AnalysisDeath RateDepressed moodDetectionDevelopmentDimensionsDouble-Blind MethodDouble-Blind StudyDouble-BlindedDouble-Masked MethodDouble-Masked StudyDysfunctionEconomicsEducational AchievementEducational StatusElderly depressionEncephalonEndotoxinsExperimental DesignsExperimental ModelsExposure toFunctional disorderFutureGeneralized Anxiety DisorderGroups at riskHealthHigh PrevalenceImpairmentIndividualInfectionInflammagingInflammationInflammatoryInterventionInvestigatorsJointsK01 AwardK01 MechanismK01 ProgramLaboratoriesLinkMedicalMental DepressionMental HealthMental HygieneMental disordersMental health disordersMentored Research Scientist Development AwardMentored Training AwardMentorsMethodologyMethodsModelingMonitorMoodsMotivationOutcomePathway interactionsPeople at riskPeripheralPersonal SatisfactionPersons at riskPhysiopathologyPlacebo ControlPlacebosPlayPopulations at RiskPre-Clinical ModelPreclinical ModelsPredispositionPreventative strategyPrevention strategyPreventive strategyProcessPsychiatric DiseasePsychiatric DisorderPsychological HealthPublic HealthResearchResearch PersonnelResearch Scientist Development AwardResearchersRewardsRiskRisk FactorsRoleScreening procedureSham TreatmentSocial isolationSpecificitySusceptibilitySystemTechniquesTestingTrainingVentral StriatumWorkadulthoodage-related inflammationagesaging associated inflammationanxiety symptomsanxiousanxious symptombehavior measurementbehavioral measurebehavioral measurementbio-markersbiologicbiologic markerbiomarkerchronic disorderclinical significanceclinically significantco-morbidco-morbiditycognitive abilitycomorbiditydaily functioningdata interpretationdepresseddepressiondepression modeldepressive modeldesigndesigningdevelopmentaldisabilitydisparities in sexdrivingeconomiceducational levelexperienceexperimentexperimental researchexperimental studyexperimentsgeriatric depressionimprovedindividual heterogeneityindividual variabilityindividual variationinflamm-ageinginflamm-aginginflammation associated with aginginsightlate in lifelate lifelate life depressionlate-life anxietymental illnessmethods to study multiple-level influencesmortalitymortality ratemortality ratiomulti-level analysismulti-level modelmultilevel analysismultilevel modelmultilevel modelingnegative moodneuralneural circuitneural circuitryneural imagingneural mechanismneuro-imagingneurocircuitryneuroimagingneurological imagingneuromechanismnovelolder adultolder adulthoodpathophysiologypathwaypersonalization of treatmentpersonalized medicinepersonalized therapypersonalized treatmentpharmacologicphysical conditioningphysical healthplacebo controlledpleasurepreventpreventingprogramspsychiatric illnesspsychological disorderpsychosocialrecruitresponsereward circuitrysadnessscreening toolssexsex disparitysham therapyskill acquisitionskill developmentsocialsocial rolesuicidal risksuicide risksynaptic circuitsynaptic circuitrytraining achievementtraining leveltraining statustreatment strategywell-beingwellbeing
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PROJECT SUMMARY/ABSTRACT
Depression in late life is prevalent, affects nearly one fifth of older adults, and exacts an enormous burden on
public health. One hallmark of late-life depression is a loss in the ability to experience pleasure and reduced
motivation to seek rewarding experiences. Loss of pleasure and motivation limits engagement in…
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