grant
Excess cardiovascular inflammation in TB and HIV: EXFIN-TB
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 1 Sept 2025Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY202521+ years oldAIDS VirusASCVDAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusActive Follow-upAcuteAddressAdultAdult HumanAfter CareAfter-TreatmentAftercareAgeAgingAirway infectionsApoplexyArteriesAssayAtherosclerosisAtherosclerotic Cardiovascular DiseaseAutomobile DrivingBeta Proprotein Interleukin 1BioassayBiological AssayBiological MarkersBloodBlood Reticuloendothelial SystemBlood VesselsBrain Vascular AccidentCXRCardiovascularCardiovascular Body SystemCardiovascular DiseasesCardiovascular Organ SystemCardiovascular systemCaringCause of DeathCell Communication and SignalingCell SignalingCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeCessation of lifeChestClinical TrialsCommunicable DiseasesCommunitiesComplexDALYDeathDeath RateDevelopmentDiagnosisDifferential Gene ExpressionDiseaseDisorderEnrollmentEpidemicEpidemiologic ResearchEpidemiologic StudiesEpidemiological StudiesEpidemiology ResearchEvaluationEventFutureGoalsHIVHIV/MtbHIV/TBHIV/mycobacterium tuberculosisHIV/tuberculosisHeart VascularHigh Resolution Computed TomographyHistoryHuman Immunodeficiency VirusesIFN-Gamma-Inducing Factor GeneIFN-gamma-Inducing FactorIGIFIGIF GeneIL-1 GammaIL-1 Gamma GeneIL-1 betaIL-1 βIL-1-bIL-18IL-18 GeneIL-1gIL-1g GeneIL-1βIL1-BetaIL1-βIL18IL18 ProteinIL18 geneIL1B ProteinIL1F2IL1F4IL1F4 GeneIL1βImageIndividualInfectionInfectious DiseasesInfectious DisorderInflammasomeInflammationInflammatoryInnate Immune ResponseInnate Immune SystemInterferon-Gamma-Inducing Factor GeneInterferon-gamma-Inducing FactorInterleukin 18 (Interferon-Gamma-Inducing Factor)Interleukin 18 (Interferon-Gamma-Inducing Factor) GeneInterleukin 18 ProproteinInterleukin 18 Proprotein GeneInterleukin 1betaInterleukin-1 GammaInterleukin-1 Gamma GeneInterleukin-1 betaInterleukin-18Interleukin-18 PrecursorInterleukin-18 Precursor GeneInterleukin-1βInterventionIntracellular Communication and SignalingIschemic HeartIschemic Heart DiseaseIschemic myocardiumKnowledgeLAV-HTLV-IIILinkLiteratureLong-term cohort studyLongitudinal cohort studyLungLung DiseasesLung InflammationLung Respiratory SystemLung TBLung TuberculosisLymphadenopathy-Associated VirusM tuberculosis infectionM. tb infectionM. tuberculosis infectionM. tuberculosis/HIVM.tb infectionM.tuberculosis infectionMGC12320MGC12320 GeneMTB infectionMacromolecular Protein ComplexesMeasuresMeta-AnalysisMolecularMorbidityMorbidity - disease rateMultiprotein ComplexesMycobacterium tuberculosis (MTB) infectionMycobacterium tuberculosis infectionMyocardial IschemiaOutcomePathologyPathway interactionsPatient CarePatient Care DeliveryPatientsPersonsPhysiologic pulsePneumonitisPreinterleukin 1 BetaPreventative strategyPrevention strategyPreventive strategyProspective StudiesProspective, cohort studyPublic HealthPulmonary DiseasesPulmonary DisorderPulmonary InflammationPulmonary TBPulmonary TuberculosisPulseRadiographyRecording of previous eventsRespiratory InfectionsRespiratory Tract InfectionsRiskRisk FactorsRoentgenographyRoleScanningSeveritiesSeverity of illnessSignal TransductionSignal Transduction SystemsSignalingSouth AfricaSputumStandardizationStressStrokeSurvivorsTB diagnosisTB infectionTB therapyTB treatmentTestingTherapeutic StudiesTherapy ResearchThoraceThoracicThoracic RadiographyThoraxTissue-Specific Differential Gene ExpressionTissue-Specific Gene ExpressionTuberculosisTuberculosis diagnosisTunica IntimaTunica Intima VasorumVascular DiseasesVascular DisorderVascular IntimaVascular agingViralVirus-HIVactive followupadulthoodagesarterial stiffeningarterial stiffnessartery stiffeningartery stiffnessatheromatosisatherosclerotic diseaseatherosclerotic vascular diseasebio-markersbiologic markerbiological signal transductionbiomarkerblood vessel disorderbrain attackcardiac ischemiacardiovascular disease riskcardiovascular disordercardiovascular disorder riskcardiovascular riskcardiovascular risk factorcare for patientscare of patientscaring for patientscarotid intima-media thicknesscerebral vascular accidentcerebrovascular accidentchest X raychest Xraychest radiographycirculating biomarkerscirculating markerscirculatory systemclinical riskco-infectioncohortcoinfectioncoronary ischemiacytokinedeath riskdevelopmentaldiagnosed with TBdiagnosed with Tuberculosisdisability-adjusted life yearsdisease of the lungdisease severitydisorder of the lungdisseminated TBdisseminated tuberculosisdrivingendothelial dysfunctionenrollepidemiologic investigationepidemiology studyfollow upfollow-upfollowed upfollowupheart ischemiahigh resolution CThigh riskhistoriesimaginginfection due to Mycobacterium tuberculosisinflammation markerinflammatory markerintima medialife year losslung disorderlung radiographymortalitymortality ratemortality ratiomortality riskmyocardial ischemia/hypoxiamyocardium ischemiapathwaypost treatmentpreventpreventingpulmonaryradiographic chest imageradiographic lung imageradiological imagingsecondary analysissecondary outcomesexsocial rolestrokedstrokessystemic inflammationsystemic inflammatory responsetherapeutic targetthoracic radiogramthorax radiographytreat M. tuberculosistreat Mtbtreat Mycobacterium tuberculosistreat tbtreat tuberculosistreatment strategytuberculosis infectiontuberculosis therapytuberculosis treatmenttuberculous spondyloarthropathyvascularvascular dysfunctionvasculature agingvasculopathyyears of life lost
Description preview
TB is the leading global killer among infectious diseases and the number one cause of death among those
with HIV. Furthermore, the estimated 9 million TB survivors completing treatment each year have a 3-fold
increased risk of death from any cause when compared to those without previous TB. While post-TB lung disease
is a major contributor to the…
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