Excellence in Research: Molecular characterization of the TLE1-mediated transcriptional and epigenetic program as a modulator of epithelial cell survival and a target of integrins

Cells on the surface of animal tissues and organs adhere for survival to an underlying extracellular matrix (ECM) of proteins via adhesion proteins called integrins. Loss of cell attachment is regulated to shed cells from these tissues via a process called programmed cell death. While direct integrin-mediated signals to downstream cell death…