grant
Examining the influence of sociodemographic and medical factors on plasma p-tau217 performance in at-risk populations
Organization VANDERBILT UNIVERSITY MEDICAL CENTERLocation NASHVILLE, UNITED STATESPosted 9 Aug 2024Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY202521+ years oldAD dementiaAD pathologyAD related dementiaADRDAdultAdult HumanAffectAfrican AmericanAfro AmericanAfroamericanAgingAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer disease screeningAlzheimer risk factorAlzheimer sclerosisAlzheimer screeningAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's and related dementiasAlzheimer's biomarkerAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease biological markerAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease pathologyAlzheimer's disease related dementiaAlzheimer's disease riskAlzheimer's pathologyAlzheimers DementiaAlzheimer’s biological markerAlzheimer’s disease biomarkerAmentiaAmyloidAmyloid SubstanceAssayAutopsyBioassayBiologic FactorBiological AssayBiological FactorsBiological MarkersBiometricsBiometryBiostatisticsBlackBlack raceBloodBlood PlasmaBlood Reticuloendothelial SystemBlood SampleBlood TestsBlood specimenChronic Kidney FailureChronic Renal DiseaseChronic Renal FailureCirrhosisClinicalClinical ManagementCognitiveCohort StudiesCollaborationsCommunitiesConcurrent StudiesConsensusCox Proportional Hazards ModelsDataData AnalysesData AnalysisDementiaDevelopmentDiagnosisDisclosureDiseaseDisorderDisparitiesDisparityEarly DiagnosisEarly InterventionEarly identificationEconomic IncomeEconomical IncomeEnsureEpidemiologyEquipmentEthnic OriginEthnicityFundingFutureGoalsGroups at riskHeadHealthHealth PlanningHealth behaviorHematologic TestsHematological TestsHematology TestingHepatic DisorderIncomeIndividualIndividual DifferencesInformation DisclosureInstitutionInternationalInterventionKidneyKidney DiseasesKidney Urinary SystemKnowledgeL-ThreonineLeadershipLinear RegressionsLiver diseasesLong-Term CareLong-term cohortLongitudinal cohortLow incomeMeasuresMediatorMedicalMedicare claimMemoryMentorsMentorshipMethodsModelingNational Institutes of HealthNephropathyObesityParticipantPathologyPeople at riskPerformancePersons at riskPhenotypePlasmaPlasma SerumPopulationPopulation HeterogeneityPopulations at RiskPrimary Senile Degenerative DementiaProceduresProductivityPublic HealthRaceRacesRacial GroupRenal DiseaseResearchResearch ResourcesResourcesReticuloendothelial System, Serum, PlasmaRiskRisk ReductionScientistSoutheast U.S.Southeast USSoutheastern United StatesTechnical ExpertiseTennesseeThreonineTrainingUnited States National Institutes of Healthadiposityadulthoodalzheimer riskbasebasesbehavior changebio-markersbiologic markerbiomarkerblood-based biomarkerblood-based markercardiovascular riskcardiovascular risk factorcareerchronic kidney diseasecirrhoticclinical implementationco-morbidco-morbiditycohortcommunity level disadvantagecomorbiditycorpulencecostdata interpretationdementia riskdevelopmentaldifferences due to racedifferences in racediffers by racediffers in racedisadvantaged communitydisparities in racedisparity due to racediverse populationsearly detectionearly screeningepidemiologicepidemiologicalexperienceextended carehealth related behaviorhepatic diseasehepatopathyheterogeneous populationimprovedin vivoincomesinequality due to raceinequity due to racekidney disorderliver disordermotivated behaviornecropsyneighborhood barrierneighborhood disadvantageneighborhood-level barrierneighborhood-level disadvantagenerve cell deathnerve cell lossneuron cell deathneuron cell lossneuron deathneuron lossneuronal cell deathneuronal cell lossneuronal deathneuronal lossolder adultolder adulthoodp-taup-τphospho-tauphospho-τphosphorylated tauplan healthpopulation diversitypost-translational modification of taupostmortemposttranslational modification of tauprimary degenerative dementiaprogramsrace based differencesrace based disparityrace based inequalityrace based inequityrace differencesrace disparityrace related differencesrace related disparityrace related inequalityrace related inequityracialracial backgroundracial differenceracial disparityracial diversityracial inequalityracial inequityracial originracial populationracial subgroupracially differentracially diverseracially unequalreduce riskreduce risksreduce that riskreduce the riskreduce these risksreduces riskreduces the riskreducing riskreducing the riskrenalrenal disorderrisk factor for dementiarisk for dementiarisk-reducingscreeningscreeningssenile dementia of the Alzheimer typesingle moleculeskillssocio-demographicssociodemographicssuccesstau phosphorylationtau posttranslational modificationtau-1technical skillstooltraining opportunityunder served communityunderserved communityτ phosphorylation
Description preview
ABSTRACT.
Alzheimer’s disease (AD) is a public health crisis that disproportionately affects individuals in the Black
community. With recent advances in treatment, the need for early identification of AD pathology has never
been greater. Early detection allows for early intervention which may be essential to slowing or stopping the
progression of…
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