grant
Examining Glycine Receptor's Intracellular Domain by Crosslinking-Mass Spectrometry
Organization DUQUESNE UNIVERSITYLocation PITTSBURGH, UNITED STATESPosted 11 Sept 2025Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY2025AgonistAnesthestic DrugsAnesthetic AgentsAnesthetic DrugsAnestheticsBaculovirus Expression SystemBindingCell BodyCellsChemicalsCommunicationComplementComplement ProteinsComplexCoupledCrosslinkerCrystallizationCrystallographiesCrystallographyDNA mutationDataDimensionsDiseaseDisorderDrugsEnvironmentGenerationsGenetic ChangeGenetic defectGenetic mutationGlycine ReceptorsGoalsHealth SciencesHumanInsectaInsectsInsects InvertebratesIntracellular StructureInvestigatorsIon Channel GatingIon Channel GatingsIvermectinKnowledgeLengthLigandsLipid BilayersLipidsMapsMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMedicationMembraneMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMethodological StudiesMethodologyMethodsMissionModern ManModificationMolecularMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular StereochemistryMutateMutationNIGMSNational Institute of General Medical SciencesNerve CellsNerve UnitNeural CellNeurocyteNeuronsPharmaceutical PreparationsPhosphatidesPhospholipidsPhysiologicPhysiologicalPositionPositioning AttributePropertyProtein RegionProteinsPublic HealthReceptor ProteinResearchResearch PersonnelResearchersResolutionRestSTEM classSTEM courseSTEM disciplineSTEM fieldSTEM majorSiteSphingolipidsStructureStudentsSubcellular structureSurface ProteinsSystemTechnical ExpertiseTechniquesTechnologyTherapeuticTrainingcomparativecomplementationconformationconformationalconformational stateconformationallyconformationscostcrosslinkdesensitizationdesigndesigningdrug/agentgenome mutationgraduate studentinsightlipid bilayer membranemass spectrometermembermembrane structuremimeticsmutantneuronalnoveloverexpressoverexpressionpharmacologicphotoactivationprotein complexprotein structureprotein structuresproteins structurereceptorreceptor functionreconstitutereconstitutionresolutionsscience, technology, engineering and math classscience, technology, engineering and math coursescience, technology, engineering and math disciplinescience, technology, engineering and math fieldscience, technology, engineering and math majorscience, technology, engineering and mathematics classscience, technology, engineering and mathematics coursescience, technology, engineering and mathematics disciplinescience, technology, engineering and mathematics fieldscience, technology, engineering and mathematics majortechnical skillsthermolabilitythermostabilityundergradundergraduateundergraduate student
Description preview
Project Summary. While high-resolution structural data are available for members of the pentameric
ligand-gated ion channel (pLGIC) superfamily in membrane-mimetic environments, the structure of
the intracellular domain (ICD) of these receptors in lipid bilayers remains unresolved. Our aims are to
conduct crosslinking mass spectrometric studies…
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