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Evolution of Pseudomonas aeruginosa in premise plumbing and impact on cystic fibrosis respiratory disease pathogenesis
Organization CARNEGIE-MELLON UNIVERSITYLocation PITTSBURGH, UNITED STATESPosted 1 May 2024Deadline 30 Apr 2026 ⚠️
NIHUS FederalResearch GrantFY2025AcuteAirway infectionsAllelesAllelomorphsAmoebaAmoeba genusAntimicrobial ResistanceAwardBacteriaBiologic ModelsBiological ModelsCCRL2CCRL2 geneCF airwayCF infectionCKRXCOPDCRAM-ACRAM-BCell BodyCell CommunicationCell Communication and SignalingCell InteractionCell SignalingCell-to-Cell InteractionCellsChemicalsChemokine (C-C Motif) Receptor-Like 2 GeneChloraminesChloroaminesChronic Obstruction Pulmonary DiseaseChronic Obstructive Lung DiseaseChronic Obstructive Pulmonary DiseaseChronic lung diseaseCommunitiesComplementComplement ProteinsCoupledCystic FibrosisDNA mutationDataDisease OutbreaksDisinfectantsDisinfectionEarEconomic BurdenEmployment ApplicationEngineeringEnvironmentEpithelial CellsEvolutionExposure toEyeEyeballFacultyFoundationsGeneralized GrowthGenesGeneticGenetic ChangeGenetic DiseasesGenetic ScreeningGenetic defectGenetic mutationGenomeGenomicsGoalsGrowthHCRHydrogen OxideImaging ProceduresImaging TechnicsImaging TechniquesImmune responseImmunocompromisedImmunocompromised HostImmunocompromised PatientImmunosuppressed HostInfectionInfection preventionInflammatoryInterventionIntracellular Communication and SignalingJob ApplicationKnowledgeLaboratoriesLifeLife StyleLifestyleLinkLipopolysaccharidesMacrophageMapsMicrobeMicrobial BiofilmsMissionModel SystemModelingMucoviscidosisMutationMφNational Institutes of HealthNutrientNutritionalNutritional ImmunityOperative ProceduresOperative Surgical ProceduresOpportunistic InfectionsOutbreaksOutcomeP aeruginosaP. aeruginosaPathogenesisPathogenicityPathway interactionsPersonsPhagocytosisPhenotypePhysiologicPhysiologicalPlumbingPopulationPositionPositioning AttributePostdocPostdoctoral FellowPrevent infectionProtocolProtocols documentationPseudomonas aeruginosaPseudomonas pyocyaneaPublic HealthPulmonary Body SystemPulmonary Organ SystemResearchResearch AssociateResidualResidual stateRespiratory DiseaseRespiratory InfectionsRespiratory SystemRespiratory System DiseaseRespiratory System DisorderRespiratory Tract InfectionsRespiratory TractsRespiratory tract structureScientistShapesSignal TransductionSignal Transduction SystemsSignalingSiteSourceStructureSurgicalSurgical InterventionsSurgical ProcedureTestingTissue GrowthTrainingTropismUnited States National Institutes of HealthUrinary tractVirulenceWaterWorkammonia chloramineanti-microbialanti-microbial resistantanti-microbial toleranceantimicrobialbiofilmbiofilm communitybiological signal transductionbronchial epitheliumburden of diseaseburden of illnesscareercareer developmentchronic obstructive pulmonary disorderchronic pulmonary diseasecomparative genomicscomplementationcystic fibrosis airwaycystic fibrosis infectiondisease burdenfitnessgenetic conditiongenetic disordergenome mutationhookahhost responseimmune phagocytosisimmune system responseimmunoresponseimmunosuppressed patientinfection in CFinfection in cystic fibrosisinsightmetatranscriptomicsmicrobialmicrobial consortiamicrobial floramicrobiotamicrofloramixed species biofilmmonochloraminemucosal sitemulti-microorganism biofilmmultispecies biofilmmultispecies consortianarghilenutritiousontogenyopportunistic pathogenpathogenpathwaypolymicrobial biofilmpost-docpost-doctoralpost-doctoral traineepressureprogramsresearch associatesresistance to anti-microbialresistant to antimicrobialresponseshishasuccesssurface coatingsurgerytherapeutic agent developmenttherapeutic developmenttissue woundtolerance to anti-microbialstraitwater pipewater-bornewaterbornewaterpipewoundwoundingwounds
Applications closed.
Description preview
Potable water is a major source of opportunistic pathogens that cause a variety of life-threatening infections in
immunocompromised people, with a yearly US economic burden of $2.4 billion dollars. Biofilms ubiquitously coat
surfaces within building premise plumbing that delivers potable water (e.g. water pipes, faucets, shower heads)
and serve as…
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