grant
Evolution of pleiotropic consequences via mucoid phage resistance in Escherichia coli populations
Organization UNIVERSITY OF WISCONSIN MILWAUKEELocation MILWAUKEE, UNITED STATESPosted 1 Sept 2025Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY2025AgarAntibiotic AgentsAntibiotic DrugsAntibiotic ResistanceAntibioticsAssayAuthorshipAutomobile DrivingAwardBacteriaBacteriophagesBeta-Lactam resistantBioassayBiological AssayCell BodyCellsClinicalCollectionDNA mutationDataE coliE. coliEcologic MonitoringEcological MonitoringEnvironmentEnvironmental MonitoringEquilibriumEscherichia coliEvolutionFrequenciesFutureGenesGeneticGenetic ChangeGenetic defectGenetic mutationGenomicsGenotypeGoalsImplantInfectionInvestigatorsKnowledgeLiquid substanceLyticMedicalMentorshipMicrobial BiofilmsMiscellaneous AntibioticMolecularMolecular GeneticsMotilityMutationNatureOutcomePathogenicityPathogenicity FactorsPatientsPhagesPhase-Contrast MicroscopyPhenotypePopulationPrevalenceProbabilityProductionProteinsPublicationsR PlasmidsReceptor ProteinResearchResearch PersonnelResearchersResistanceResistance to antibioticsResistant to antibioticsSalariesScienceScientific PublicationSerial PassageStructureSurfaceSwimmingTestingTherapeuticVirulenceVirulence FactorsWagesWorkalternative treatmentantibiotic drug resistanceantibiotic effluxantibiotic exportantibiotic resistantb lactam resistanceb-lactam resistantbacterial geneticsbacterial virusbalancebalance functionbeta lactam antibioticbeta-Lactam Resistancebeta-Lactamsbiofilmcostdesigndesigningdrivingefflux pumpenvironmental testingexperimentexperimental researchexperimental studyexperimentsfitnessfluidgenome mutationinnovateinnovationinnovativeinterestliquidmucoidmutantpathogenpedagogypleiotropic effectpleiotropismpleiotropypressurereceptorresistance against beta lactamsresistance factorsresistance generesistance locusresistance mechanismresistance mutationresistance to b lactamresistance to beta-lactamresistance to β-Lactamresistantresistant generesistant mechanismresistant mutationresistant to b lactamresistant to beta-lactamresistant to β-Lactamside effecttest striptherapeutic candidatetherapeutic outcometherapy outcometraitundergradundergraduateundergraduate researchundergraduate studentβ lactam antibioticβ-Lactam Resistanceβ-Lactam resistantβ-Lactams
Description preview
PROJECT SUMMARY
Pleiotropy, which occurs when a genetic change alters two or more phenotypes, can be observed during
pathogen evolution when resistance to one treatment results in sensitivity to another treatment. Prior research
suggests that bacteriophage-based alternatives to antibiotics can be more effective when phage resistance
comes at a…
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