grant
Evaluation of the neuroimmune mechanisms influencing therapeutic targetingpotential of the LH/CG receptor in the menopausal and AD brain
Organization UNIVERSITY OF FLORIDALocation GAINESVILLE, UNITED STATESPosted 1 Sept 2025Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY2025AD dementiaAD modelAD pathologyAPP-PS1APP/PS1AccelerationAddressAffectAgeAgingAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's brainAlzheimer's disease brainAlzheimer's disease modelAlzheimer's disease pathologyAlzheimer's disease riskAlzheimer's pathologyAlzheimers DementiaAmmon HornAmyloidosisApoplexyAutomobile DrivingAutoregulationBBB disruptionBrainBrain Nervous SystemBrain Vascular AccidentCNS plasticityCell BodyCell Communication and SignalingCell SignalingCellsCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeChemotactic CytokinesChoriogonadotropinChorionic GonadotropinChronicCognitionCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalComplexCornu AmmonisCytokine GeneDataDevelopmentDiseaseDisorderDisturbance in cognitionDoseEffectivenessEncephalonEndocrine Gland SecretionEndocrine TherapyEnvironmentEpilepsyEpileptic SeizuresEpilepticsEvaluationEventFemaleFosteringGene TranscriptionGenesGenetic TranscriptionGoalsGonadotropinsHealthHippocampusHomeostasisHomologous Chemotactic CytokinesHormonal TherapyHormone ReceptorHormonesHortega cellHumanHuman Chorionic GonadotropinImmuneImmune RegulatorsImmune infiltratesImmunesImmunologic ReceptorsImmunological ReceptorsImmunomodulatorsImpaired cognitionInfectionInfiltrationInflammationInflammatoryInjuryIntercrinesInterstitial Cell Stimulating HormoneInterstitial Cell-Stimulating HormoneIntracellular Communication and SignalingLeuteinizing HormoneLigandsLinkLuteinizing HormoneLutropinMeasuresMediatingMediatorMenopauseMiceMice MammalsMicrogliaModelingModern ManMurineMusMyelogenousMyeloidMyeloid CellsNerve CellsNerve UnitNeural CellNeurocyteNeuroendocrineNeuroendocrine SystemNeuroimmuneNeuroimmune MechanismsNeuroimmune ProcessesNeuroimmunomodulationNeurologicNeurologicalNeuronal PlasticityNeuronsNeurosecretory SystemsOophorectomyOutcomeOvarian hormoneOvariectomyPathogenesisPathogenicityPathologyPeripheralPhenotypePhysiological HomeostasisPituitary HormonesPituitary Lutenizing HormonePregnancy MaintenancePrimary Senile Degenerative DementiaProcessPropertyRNA ExpressionRNA SeqRNA sequencingRNAseqReceptor ActivationReceptor ProteinReceptor SignalingRecombinant Luteinizing HormoneRegulationReporterRisk FactorsRodentRodentiaRodents MammalsRoleSIS cytokinesSeizure DisorderSentinelSignal TransductionSignal Transduction SystemsSignalingStrokeSurfaceTamoxifenTestingTherapeuticTherapeutic EffectTherapeutic HormoneTherapeutic LHTranscriptionVascular remodelingWomanWorkadverse consequenceadverse outcomeage associatedage associated effectsage correlatedage dependentage effectage linkedage relatedage related effectsage specificagesaging effectalzheimer modelalzheimer riskamyloid diseasebeta amyloid associated pathologybeta amyloid pathologybiological signal transductionblood-brain barrier disruptionbloodbrain barrier disruptionbrain attackcell typecentral nervous system plasticitycerebral vascular accidentcerebrovascular accidentchemoattractant cytokinechemokinecognitive assessmentcognitive dysfunctioncognitive functioncognitive losscognitive testingcomparing females and malescomparing women and mencytokinedementia riskdesigndesigningdevelopmentaldrivingepilepsiaepileptogenicexcitatory neuronfemale gonadectomyfemale outcomesfemales compared to malesfemales compared with malesfemales versus malesfemales vs. malesgitter cellglobal gene expressionglobal transcription profilehCGhippocampalhormonal signalshormone signalshormone therapyimmune cell infiltrateimmune modulatorsimmune receptorimmunomodulatory moleculesimmunoregulatorimmunoregulatory moleculesimpact of ageinflammatory environmentinflammatory milieuinfluence of ageinjuriesinsightknowledge basemaintain pregnancymesogliamicroglial cellmicrogliocytemid lifemid-lifemiddle agemiddle agedmidlifeneural inflammationneural plasticityneuroinflammationneuroinflammatoryneuronalneuroplasticneuroplasticityneuroprotectionneuroprotectivenoveloutcomes among femalesoutcomes among womenoutcomes in femalesoutcomes in womenperivascular glial cellprimary degenerative dementiareceptorreceptor expressionreproductiverisk factor for dementiarisk for dementiascRNA sequencingscRNA-seqsenescencesenescentsenile dementia of the Alzheimer typesingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolestrokedstrokestherapeutic outcometherapeutic targettherapy outcometranscriptometranscriptome sequencingtranscriptomic sequencingwomen compared to menwomen compared with menwomen versus menwomen vs. menwomen's outcomesβ-amyloid pathology♀
Description preview
PROJECT SUMMARY
Menopause is midlife event that promotes adverse outcomes in the female brain. The systemic
proinflammatory state induced by large fluctuations and changes in ovarian and pituitary hormones is thought to
exacerbate peripheral and centrally mediated neuroinflammation that increase the risk of AD in women
compared to men. Our…
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