grant
Evaluation of radon progeny and air pollution effects in asthma
Organization BOSTON CHILDREN'S HOSPITALLocation BOSTON, UNITED STATESPosted 11 Aug 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY20250-11 years old3-10CAMCF-IAbsenteeismAffectAir PollutantsAir PollutionAllergensAllergic DiseaseAsthmaAsthma in ChildrenAwardB cell differentiation factorB cell stimulating factor 2B-Cell Differentiation FactorB-Cell Differentiation Factor-2B-Cell Stimulatory Factor-2BCDFBSF-2BSF2Basic Fibroblast Growth FactorBasic Fibroblast Growth Factor GeneBiologicalBiological MarkersBlood SerumBronchial AsthmaCOPDCXCL8Cellular injuryChildChild HealthChild YouthChildhoodChildhood AsthmaChildren (0-21)Chronic DiseaseChronic IllnessChronic Obstruction Pulmonary DiseaseChronic Obstructive Lung DiseaseChronic Obstructive Pulmonary DiseaseClinical InvestigatorClinical TrialsCollaborationsDataData ReportingDevelopmentDiagnosisEarthEducational ActivitiesEndogenous Nitrate VasodilatorEndothelium-Derived Nitric OxideEnrollmentEnvironmentEnvironmental EpidemiologyEnvironmental ExposureEnvironmental FactorEnvironmental Risk FactorEpidemiologyEvaluationExhalationExhalingExposure toFGF-2FGF2FGF2 geneFGFBFibroblast Growth Factor 2Fibroblast Growth Factor 2 GeneFundingGCP1GasesGoalsHBGF-2HEPA FilterHEPA FiltrationHEPA cleanerHPGFHealthHealth Care UtilizationHeparin-Binding Growth Factor 2Heparin-Binding Growth Factor Class IIHepatocyte-Stimulating FactorHospital AdmissionHospitalizationHybridoma Growth FactorIFN-beta 2IFNB2IL-6IL-8IL6 ProteinIL8IL8 geneIndoor Air PollutionInflammationInflammatoryInfrastructureInhalationInhalingInstitutionInterleukin-6InterventionIntervention StudiesIntervention TrialInterventional trialInvestigatorsK60LearningLinkLongitudinal StudiesLungLung Respiratory SystemMGI-2Malignant Tumor of the LungMalignant neoplasm of lungMeasuresMentorsModelingMononitrogen MonoxideMorbidityMorbidity - disease rateMyeloid Differentiation-Inducing ProteinNational Institutes of HealthNitric OxideNitrogen MonoxideNitrogen ProtoxideObstructive Lung DiseasesOutcomeOutcomes ResearchOxidative StressPM2.5ParticipantParticulate MatterPatientsPediatric asthmaPeer ReviewPersonsPhenotypePhysical assessmentPhysical environmentPlanet EarthPlasmacytoma Growth FactorPoliciesPopulationProstate Epithelial Cell Growth FactorProtocolProtocols documentationPublic Health SchoolsPublic PolicyPublicationsPulmonary Body SystemPulmonary CancerPulmonary Organ SystemPulmonary malignant NeoplasmR-Series Research ProjectsR01 MechanismR01 ProgramRadiationRadioactiveRadioactive IsotopesRadioactivityRadioisotopesRadionuclidesRadonRegulationResearchResearch GrantsResearch PersonnelResearch Project GrantsResearch ProjectsResearch ResourcesResearchersResourcesRespiratory ExpirationRespiratory SystemRespiratory TractsRespiratory tract structureRiskRisk FactorsRn elementRoleSCYB8SamplingSchool-Age PopulationSchoolsScientific PublicationSerumShapesStudentsSymptomsTSG-1TestingTimeTrainingU elementUnited StatesUnited States National Institutes of HealthUniversitiesUraniumair cleanerairway epithelium inflammationairway inflammationasthma attackasthma exacerbationb-ENAPbFGFbio-markersbiologicbiologic markerbiomarkerbiomarker identificationcarcinogenicitycareercareer developmentcatalystcell damagecell injurycellular damagechronic disorderchronic obstructive pulmonary disorderclinical investigationcohortcomputer based predictiondamage to cellsdata representationdata representationsdesigndesigningdevelopmentaldisabilityelementary schoolendothelial cell derived relaxing factorenrollenvironmental riskepidemiologicepidemiologicalexacerbation in asthmaexacerbation prone asthmaexacerbation prone asthmaticfine particlesfine particulate mattergrade schoolhealth care service usehealth care service utilizationhigh efficiency particulate air cleanerhigh efficiency particulate air filterhigh-efficiency particulate air purifieridentification of biomarkersidentification of new biomarkersimprovedindoor air contaminationindoor air pollutantindoor allergenindoor exposureindoor pollutantinjury to cellsinner cityinterferon beta 2intervention researchinterventional researchinterventional studyinterventions researchkidslong-term studylongitudinal outcome studieslung cancerlung functionmalleable riskmarker identificationmodifiable riskmortalitynovelobstructive pulmonary diseasesparent grantparticleparticle exposurepediatricpollutantpredictive modelingprogramspublic health interventionpulmonary functionradioactivitiesremediationrespiratory inflammationrespiratory tract inflammationresponseschool ageskillssocial rolespatial and temporalspatial temporalspatiotemporalyoungster
Description preview
PROJECT SUMMARY/ABSTRACT
Research: Children exposed to indoor air pollution are known to more likely develop asthma, and in those with
asthma, indoor air pollution can worsen asthma symptoms. Radon (Rn), a radioactive gas known for its lung
cancer effects, decays into radiation-emitting progeny which has potential to induce cellular damage once…
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