grant

Evaluation of Long Acting Injectable (LAI) and Teen clubs in adolescents (ATTUNE)

Organization KWAZULU-NATAL RESEARCH INSTITUTE TB-HIVLocation Durban, SOUTH AFRICAPosted 24 Sept 2023Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY20250-11 years old12-20 years oldAIDS VirusAIDS preventionAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusActive Follow-upAddressAdherenceAdolescenceAdolescentAdolescent HIVAdolescent YouthAdoptionAfrica South of the SaharaAgeAssess implementationBehavior Conditioning TherapyBehavior ModificationBehavior TherapyBehavior TreatmentBehavioral Conditioning TherapyBehavioral ModificationBehavioral TherapyBehavioral TreatmentCaringCessation of lifeChildChild YouthChildren (0-21)ClinicClinicalClinical TrialsCohort StudiesConcurrent StudiesConditioning TherapyConflictConflict (Psychology)Continuity of CareContinuity of Patient CareContinuum of CareCounselingDeathDeath RateDisclosureDoseDrugsEffectivenessEnrollmentEvaluationFailureFatigueFeedbackFilmFosteringFriendsFundingHIVHIV PreventionHIV infection in adolescenceHIV infections in adolescentsHIV-infected (HIV+) adolescentsHIV-infected adolescentsHIV/AIDS preventionHealthHealth systemHuman Immunodeficiency VirusesImplementation assessmentImprove AccessIndividualInfectionInformation DisclosureInjectableInternationalInterventionInvestigatorsKnowledgeLAV-HTLV-IIILMICLack of EnergyLifeLow-resource areaLow-resource communityLow-resource environmentLow-resource regionLow-resource settingLymphadenopathy-Associated VirusMaintenanceMalawiMeasuresMedicationNational Institutes of HealthNyasalandOralOutcomePatientsPerinatalPeripartumPharmaceutical PreparationsProtocolProtocols documentationPublishingRE-AIMRandomizedRandomized, Controlled TrialsReach, Effectiveness, Adoption, Implementation, and MaintenanceRecommendationResearchResearch PersonnelResearchersResource-constrained areaResource-constrained communityResource-constrained environmentResource-constrained regionResource-constrained settingResource-limited areaResource-limited communityResource-limited environmentResource-limited regionResource-limited settingResource-poor areaResource-poor communityResource-poor environmentResource-poor regionResource-poor settingSchoolsServicesShameSiteSocial supportSouth AfricaStandardizationSub-Saharan AfricaSubsaharan AfricaSupervisionTeenTeenagersTimeTrainingUnited States National Institutes of HealthViralViral BurdenViral LoadViral Load resultVirus-HIVVisitacceptability and feasibilityactive followupadolescence (12-20)adolescents living with HIVadolescents with HIVagesantiretroviral therapyantiretroviral treatmentarmassess effectivenessbehavior changebehavior interventionbehavioral interventioncostcost effectivedetermine effectivenessdrug/agenteffectiveness assessmenteffectiveness evaluationeffectiveness/implementation designeffectiveness/implementation hybrid designenrollevaluate effectivenessevaluate implementationevaluation of implementationexamine effectivenessexperiencefollow upfollow-upfollowed upfollowupforgettingimplementation determinantsimplementation evaluationimplementation factorsimplementation scienceimplementation strategyimprovedimproved outcomeinnovateinnovationinnovativejuvenilejuvenile humankidslow and middle-income countriesmedication administrationmeetingmeetingsmortalitymortality ratemortality ratioolder adultolder adulthoodpeerperi-urbanperiurbanpillprogramspublic health relevancerandomisationrandomizationrandomized control trialrandomized, clinical trialsrandomly assignedreach, efficacy, adoption, implementation, and maintenancerural arearural locationrural regionsatisfactionscale upsecondary outcomeservice deliveryside effectsocialsocial stigmasocial support networkstandard carestandard of carestandard treatmentstigmastrategies for implementationsuccessful interventionteen yearsteenagetooltreatment adherencetreatment complianceuptakeurban areaurban locationurban regionyoungster
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The 1.7 million adolescents living with HIV (ALHIV) globally urgently need interventions to help improve retention, adherence, and ultimately viral load suppression (VLS). With both high rates of incident infection and some of the lowest VLS rates, ALHIV experience high mortality with approximately 100 deaths per day. Successful interventions to…

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