grant
Evaluation of GLP-1 receptor agonists on alcohol-related behaviors
Organization UNIV OF NORTH CAROLINA CHAPEL HILLLocation CHAPEL HILL, UNITED STATESPosted 1 May 2026Deadline 31 Jan 2031
NIHUS FederalResearch GrantFY2026AcuteAffectAgonistAlcohol Chemical ClassAlcohol DrinkingAlcohol consumptionAlcoholic beverage heavy drinkerAlcoholsAnteriorAntidiabetic HormoneAttentionBehaviorBody Weight decreasedBrain regionCalciumCalcium Ion SignalingCalcium SignalingClinical ResearchClinical StudyClinical TrialsCognitionCommon Rat StrainsCuesDiabetes MellitusDoseDrug usageDrugsEtOH drinkingEtOH useEthanol MetabolismEvaluationFDA approvedFemaleFiberFoodFunctional MRIFunctional Magnetic Resonance ImagingFutureGIP receptorGLP-1 RAGLP-1 agonistGLP-1 analogGLP-1 receptor agonistGeneralized GrowthGlucagonGlucagon like peptide 1 agonistGlucagon like peptide-1 receptor agonistsGlucagon-like peptide-1 analogGlucose-Dependent Insulinotropic PolypeptideGlukagonGrowthHG-FactorHeavy DrinkerHyperglycemic-Glycogenolytic FactorIndividualInjectionsInvestigationLinkMarketingMeasuresMedicationMotivationNerve CellsNerve UnitNeural CellNeurocyteNeuronsNucleus AccumbensObesityOzempicPatientsPharmaceutical PreparationsPhase 3 Clinical TrialsPhase III Clinical TrialsPhotometryProceduresPublic HealthRatRats MammalsRattusReportingRewardsRybelsusSaccharoseSelf AdministeredSelf AdministrationSucroseTechniquesTestingTherapeuticTissue GrowthWegovyWeight LossWeight Reductionadiposityalcohol abuse therapyalcohol abuse treatmentalcohol behavioralcohol cuealcohol effectalcohol induced behavioralcohol ingestionalcohol intakealcohol metabolismalcohol product usealcohol reinforcementalcohol related behavioralcohol related cuealcohol responsealcohol sensitivityalcohol treatmentalcohol usealcohol use disorderalcoholic beverage consumptionalcoholic drink intakebehavior outcomebehavioral outcomebody weight losscingulate cortexcorpulencecostdiabetesdrinkingdrinking behaviordrug discriminationdrug usedrug/agentethanol behaviorethanol consumptionethanol cueethanol drinkingethanol effectethanol induced behaviorethanol ingestionethanol intakeethanol product useethanol reinforcementethanol related behaviorethanol responseethanol sensitivityethanol useethanol use disorderexperimentexperimental researchexperimental studyexperimentsfMRIgastric inhibitory polypeptide receptorglucose-dependent insulinotropic polypeptide receptorinnovateinnovationinnovativemaleneuralneuronalontogenyphase III protocolpre-clinicalpreclinicalpreferencereinforcerresponseresponse to alcoholresponse to ethanolscreeningscreeningssemaglutidesensitivity to alcoholsensitivity to ethanoltranslational studywt-loss♀♂
Description preview
Project Summary
Alcohol use disorder (AUD) is a pressing public health issue and treatments are much needed. Glucagon-like
peptide-1 receptor agonist (GLP-1RA) compounds (e.g., Ozempic, Wegovy, Mounjaro) have been receiving
tremendous media attention for their dramatic weight loss effects. With this popularity have come media and
anecdotal reports…
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