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Evaluating the Role of Human Obesity Genes in Specific Neuronal Populations in vivo by CRISPRi
Organization UNIVERSITY OF CALIFORNIA BERKELEYLocation BERKELEY, UNITED STATESPosted 1 Dec 2024Deadline 31 Dec 2025 ⚠️
NIHUS FederalResearch GrantFY202621+ years oldACTH-beta-Lipotropin PrecursorAblationAdeno-Associated VirusesAdultAdult HumanAdult-Onset Diabetes MellitusAffectAllelesAllelomorphsAlstrom syndromeAlstrom-Hallgren syndromeAlström SyndromeAnatomic SitesAnatomic structuresAnatomyApoplexyArcuate NucleusAutoregulationBardet Biedel syndromeBardet-Biedl SyndromeBody WeightBrain Vascular AccidentCRISPRCRISPR interferenceCRISPR-dCas9-mediated repressionCRISPR/Cas systemCRISPR/dCas9 interferenceCRISPR/dCas9-mediated transcriptional inhibitionCRISPRiCancersCardiac infarctionCause of DeathCell BodyCell Communication and SignalingCell Membrane ExtensionsCell Membrane ProjectionsCell Membrane ProtrusionsCell SignalingCell Surface ExtensionsCell Surface ProjectionsCell Surface ProtrusionsCell modelCellsCellular modelCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeCiliaClustered Regularly Interspaced Short Palindromic RepeatsClustered Regularly Interspaced Short Palindromic Repeats interferenceComplexCorticotropin-beta-Lipotropin PrecursorDNA mutationDataDefectDependoparvovirusDependovirusDevelopmentDown-RegulationEatingEndorphin-ACTH PrecursorEpistasisEpistatic DeviationFamily StudyFood IntakeGene AlterationGene Down-RegulationGene ExpressionGene MutationGene TranscriptionGenesGenetic ChangeGenetic DiversityGenetic EpistasisGenetic TranscriptionGenetic VariationGenetic defectGenetic mutationGuide RNAHeritabilityHomeostasisHumanHypertensionHypothalamic structureHypothalamusInfundibular NucleusInteraction DeviationIntracellular Communication and SignalingKetosis-Resistant Diabetes MellitusLaboratoriesLeptinMC4 ReceptorMalignant NeoplasmsMalignant TumorMaturity-Onset Diabetes MellitusMediatingMelanocortin 4 ReceptorMiceMice MammalsModelingModern ManMorbid ObesityMurineMusMutationMyocardial InfarctMyocardial InfarctionNIDDMNerve CellsNerve UnitNeural CellNeurocyteNeuronsNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusOb Gene ProductOb ProteinObese Gene ProductObese ProteinObesityOrganellesOutputParaventricular Hypothalamic NucleusPatientsPersonsPhysiologicPhysiologicalPhysiological HomeostasisPopulationPro-ACTH-EndorphinPro-Opio-MelanocortinPro-OpiocortinPro-OpiomelanocortinProopiocortinProopiomelanocortinProteinsPublic HealthQuality ControlRNA ExpressionReceptor, Melanocortin, Type 4RegulationResearchResearch ProposalsRiskRoleSevere obesitySignal TransductionSignal Transduction SystemsSignalingSlow-Onset Diabetes MellitusSpecificityStable Diabetes MellitusStrokeStructure of nucleus infundibularis hypothalamiSystemT2 DMT2DT2DMTechnologyTestingTherapeuticTranscriptionTranscription RepressionTwin StudiesType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesValidationVariantVariationVascular Hypertensive DiseaseVascular Hypertensive DisorderWorkadeno associated virus groupadenylyl cyclase IIIadenylyl cyclase type IIIadiposityadult onset diabetesadulthoodbiological signal transductionbrain attackcancer typecardiac infarctcell typecerebral vascular accidentcerebrovascular accidentciliopathycoronary attackcoronary infarctcoronary infarctioncorpulencedevelopmentalepistatic interactionepistatic relationshipextreme obesityfamily focused studyfamily surveygRNAgene defectgene manipulationgene repressiongene x gene interactiongenetic epistasesgenetic etiologygenetic manipulationgenetic mechanism of diseasegenetically manipulategenetically perturbgenome mutationheart attackheart infarctheart infarctionhigh blood pressurehuman diseasehyperpiesiahyperpiesishypertensive diseasehypertensive disorderhypothalamicimprovedin vivoinduced Creinducible Creketosis resistant diabetesmalignancymaturity onset diabetesmutant alleleneoplasm/cancerneuronalparaventricular nucleusrepressing CRISPR-dCas9 systemsocial rolestrokedstrokestooltype 2 DMtype II DMtype two diabetesvalidations
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Description preview
PROJECT ABSTRACT
Obesity leads to an increased risk for type 2 diabetes, heart attack, hypertension, stroke, and many types of
cancer—conditions which are among the leading causes of death in the US. Through twin and family studies,
obesity has been found to have a 40-70% heritability rate, pointing to a strong genetic etiology.
The long-term…
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