grant

Evaluating the impact of psychotherapeutic advertising claims on cannabis purchasing

Organization DARTMOUTH COLLEGELocation HANOVER, UNITED STATESPosted 1 Jun 2025Deadline 31 May 2027
NIHUS FederalResearch GrantFY202521+ years old9-ene-TetrahydrocannabinolAddressAdultAdult HumanAdvertisingAlcohol Chemical ClassAlcoholsAnxietyBehaviorBiometricsBiometryBiostatisticsCannabisCannabis lawCannabis policyCannabis retailD9-tetrahydrocannabinolDelta-9-TetrahydrocannabinolDevelopmentEducationEducational aspectsEmotional DepressionEnvironmentEpidemiologyEvaluationExperimental DesignsExposure toFatigueFoodFrequenciesFutureGoalsHappinessHarm MinimizationHarm ReductionHealthHealth Care TechnologyHealth TechnologyIndividualIndustryInterventionLaboratoriesLack of EnergyLightLinkMarijuanaMarketingMental DepressionMental HealthMental HygieneMental disordersMental health disordersMotor VehiclesNIDANamesNational Institute of Drug AbuseNational Institute on Drug AbuseOutcomeParticipantPatternPhotoradiationPilot ProjectsPoliciesPriceProxyPsychiatric DiseasePsychiatric DisorderPsychological HealthPublic HealthQualifyingRandomizedRegulationReportingResearchResearch DesignRiskSalesScienceSensorySeveritiesStimulusStressStudy TypeSymptomsTHC co-useTHC exposureTHC useTestingTetrahydrocannabinolTetrahydrocannabinol co-useTetrahydrocannabinol useTobaccoUS StateVulnerable Populationsaddictionaddictive disorderadulthoodalleviate symptomameliorating symptomanxiety symptomsanxious symptomcannabis legalizationcannabis marketcannabis marketplacecannabis regulationcannabis usecannabis use lawcannabis use policycannabis userco-occurring disordersdecrease symptomdelta(1)-THCdelta(1)-Tetrahydrocannabinoldelta(9)-THCdelta(9)-Tetrahydrocannabinoldemographicsdepressiondepression symptomdepressivedepressive symptomsdevelopmentaldigital healthdigital platformdual diagnosiseffective therapyeffective treatmentepidemiologicepidemiologicalevidence baseexperiencefewer symptomsgeneralized anxietyimprovedinsightlegal marijuanalegalized cannabislegalized marijuanamarihuanamarijuana lawmarijuana legalizationmarijuana policymarijuana retailmarijuana usemarijuana usermental illnessmilligrammultidisciplinarynamenamednamingonline versionpilot studypricingprimary outcomepsychiatric illnesspsychological disorderrandomisationrandomizationrandomly assignedreduce symptomsrelieves symptomssell cannabissell marijuanastudy designsymptom alleviationsymptom reductionsymptom reliefsymptomatologytetrahydrocannabinol exposuretoolvulnerable groupvulnerable individualvulnerable peoplewarning labelweb sitewebsiteΔ(1)-THCΔ(1)-tetrahydrocannabinolΔ(9)-THCΔ(9)-tetrahydrocannabinolΔ-9-tetrahydrocannabinolΔ9-tetrahydrocannabinol
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Full Description

PROJECT SUMMARY
In the U.S., legal cannabis is frequently advertised as an effective treatment for mental health

problems such as anxiety and depression – particularly online. States that have legalized

cannabis have not implemented regulations to address this type of advertising. This project

aims to investigate the influence of psychotherapeutic advertising claims (PAC) and mental

health warning labels (WL) on online cannabis purchasing behaviors among light-to-moderate

cannabis users with symptoms of depression and/or anxiety. The specific aims are to determine

if PAC increases cannabis purchasing intentions and if a mental health WL can mitigate this

effect. A realistic online cannabis shopping experience will be simulated using the digital

“Platform for Online Evaluation of Marijuana Marketing and Sales” (POEMMS). The study will

employ a between-subjects experimental design by randomizing 2,000 participants to one of

four online stores that vary in PAC and WL content: (1) a control claims (CC) only store, (2) a

PAC store, (3) a WL store, and (4) a PAC and WL store. Participants will browse and select

items as if making real purchases. Analyses will examine three primary outcomes to determine

the influence of PAC and WL on purchase behaviors: (1) total milligrams of THC purchased, (2)

average potency (%THC) of products, and (3) overall number of products purchased. The long-

term objective is to inform evidence-based cannabis policy and regulatory strategies by

understanding the impact of cannabis marketing on vulnerable populations. This research is

relevant to public health by addressing the potential risks associated with misleading cannabis

marketing, which may lead to increased use and exacerbation of mental health symptoms

among individuals with depression and anxiety. The project leverages a multidisciplinary team

with expertise in addiction, mental health, epidemiology, and digital health technology. The

findings have the potential to inform the development of targeted interventions and policies to

reduce harms associated with cannabis advertising, ultimately contributing to better health

outcomes and more effective regulation.

Grant Number: 1R21DA062816-01
NIH Institute/Center: NIH

Principal Investigator: Jacob Borodovsky

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