grant
Evaluating the Cell-Type Specificity and Cellular Targets of Senotherapuetic Compounds with Unknown Mechanisms
Organization NATIONAL INSTITUTE ON AGINGLocation UNITED STATES
NIHUS FederalResearch GrantFY20252-Phenyl-Benzopyrans2-Phenyl-ChromenesAnthocyaninsApigeninAssayBinding ProteinsBioassayBiological AssayBlood monocyteCell AgingCell BodyCell Culture TechniquesCell SenescenceCell membraneCellsCellular AgingCellular SenescenceCessation of lifeComputer Software ToolsCyanidinCytoplasmic MembraneDataDeathDietary FlavonoidDoseDrug ModulationDrug ScreeningDrugsEpithelial CellsFlavonoidsFutureGenesIntakeInterventionIonsLigand Binding ProteinLigand Binding Protein GeneMarrow monocyteMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMeasuresMediatingMediatorMedicationMethodsModelingNatural CompoundPathway interactionsPharmaceutical PreparationsPlasma MembraneProcessProcyanidinsProtein BindingProteinsProteomicsPublishingQuercetinReceptor ProteinRenal CellReplicative SenescenceShort interfering RNASmall Interfering RNASoftware ToolsSpecificityTestingWorkbound proteincell culturecell culturescell typecellular targetingchemoproteomicscomputational pipelinesdetermine efficacydrug/agentefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationepicatechinevaluate efficacyexamine efficacyfisetingene manipulationgenetic manipulationgenetically manipulategenetically perturbimprovedin vivoinhibitorkidney cellknock-downknockdownmetermonocytemouse modelmurine modelmyricetinnaturally occurring compoundnovelpathwayplasmalemmareceptorrenal epitheliumreplicative agingresponsescreeningscreeningssenescencesenescentsenescent cellsenolyticssiRNAsoftware toolkituptake
Description preview
We initially screened eight flavonoids for senolytic activity (i.e., fisetin, myricetin, quercetin, apigenin, epicatechin, cyanidin c1, gingerenone, and procyanidin c1). Of these, fisetin and quercetin showed senescence specific senolytic activity in a dose-response study in both monocytes and renal epithelial cells. Myricetin, a structurally…
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