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Evaluating a Mechanistically-Supported Pharmacotherapy to Treat Acute and Protracted Opioid Withdrawal

Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 1 Aug 2022Deadline 1 Sept 2025 ⚠️
NIHUS FederalResearch GrantFY20255-HT5-HT pathway5-HT system5-HT(1A) Receptor5-HT1A Receptor5-Hydroxytryptamine5-Hydroxytryptamine 1A Receptor5HTAcheAcuteAddressAgonistAmbulatory CareAnxietyBiochemicalBloodBlood Reticuloendothelial SystemBuprenorphineBuspironeCaringCell BodyCellsClinicalD2 receptorDRD2 ReceptorDataDopamineDopamine D2 ReceptorDoseDouble-Blind MethodDouble-Blind StudyDouble-BlindedDouble-Masked MethodDouble-Masked StudyDropoutDrug TherapyDrugsEconomic BurdenEnrollmentEnteramineEvaluationFDA approvedHippophaineHydroxytyramineIndividualInfumorphInpatientsKadianLabelMS ContinMSirMarketingMeasurementMeasuresMedicationMethodsMolecular ConfigurationMolecular ConformationMolecular StereochemistryMorphiaMorphineMuscleMuscle TissueNalorexNaltrexoneNemexinOpiatesOpioidOramorphOramorph SROut-patientsOutpatient CareOutpatientsParticipantPatientsPersonsPharmaceutical PreparationsPharmacological TreatmentPharmacotherapyPhasePilot ProjectsPlacebo ControlPlacebosPublishingRandomizedReViaReceptor ProteinRelapseReportingResearch DesignResearch SupportResidential TreatmentRisk ReductionRodentRodentiaRodents MammalsRoxanolSafetySamplingSerotonergic SystemSerotoninSerotonin 1A ReceptorSerotonin Receptor 5-HT1ASeveritiesSham TreatmentStandardizationStatex SRStressStudy TypeSystemTreatment outcomeUrinalysisVisitVivitrolWithdrawalWithdrawal Symptomantagonismantagonistboneconformationconformationalconformational alterationconformational stateconformationallyconformationscravingdepression modeldepressive modeldesensitizationdetermine efficacydiariesdisease riskdisorder riskdrug interventiondrug treatmentdrug/agentefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationenrollevaluate efficacyexamine efficacyimprovedinpatient careinpatient servicemalemuscularopiate consumptionopiate crisisopiate drug useopiate intakeopiate useopiate use disorderopiate withdrawalopioid consumptionopioid crisisopioid detoxopioid detoxificationopioid drug useopioid epidemicopioid intakeopioid taperingopioid useopioid use disorderopioid withdrawaloutpatient treatmentpharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspilot studyplacebo controlledpre-clinicalpre-clinical researchpre-clinical studypreclinicalpreclinical researchpreclinical studyprevent relapseprimary outcomerandomisationrandomizationrandomly assignedreceptorreduce riskreduce risksreduce that riskreduce the riskreduce these risksreduces riskreduces the riskreducing riskreducing the riskrelapse preventionrelapse riskresidential carerisk-reducingserotonergic pathwayserotonin pathwayserotonin systemsham therapystudy designtreatment planning♂

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Description preview

There is substantial need to improve treatment for opioid use disorder (OUD). Buspirone is a mechanistically
supported medication with robust preclinical and preliminary clinical support for treating opioid withdrawal and
decreasing relapse. Buspirone has the utility to treat both acute and protracted withdrawal periods. We are
experts in the…

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