grant
Establishing translational neuroimaging tools for quantitative assessment of energy metabolism and metabolic reprogramming in healthy and diseased human brain at 7T
Organization UNIVERSITY OF MINNESOTALocation MINNEAPOLIS, UNITED STATESPosted 1 Jun 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025ADP Phosphocreatine PhosphotransferaseATP Creatine PhosphotransferaseATP phosphohydrolaseATPaseAdenosine TriphosphataseAdenosine TriphosphateAdenylpyrophosphateAffectAgingApoplexyAreaAutoregulationBiochemicalBioenergeticsBiomedical ResearchBrainBrain DiseasesBrain DisordersBrain NeoplasiaBrain NeoplasmsBrain Nervous SystemBrain TumorsBrain Vascular AccidentBrain imagingCancersCell Communication and SignalingCell RespirationCell SignalingCellular RespirationCerebral StrokeCerebrovascular ApoplexyCerebrovascular CirculationCerebrovascular StrokeCerebrumCitric Acid CycleClinicalClinical ResearchClinical StudyCollaborationsComplexConsumptionCreatine KinaseCreatine Kinase-BCreatine Kinase-B ChainCreatine PhosphokinaseD-GlucoseDegenerative Neurologic DisordersDeuteriumDextroseDiagnosisDihydronicotinamide Adenine DinucleotideDiphosphopyridine NucleotideDiseaseDisorderEncephalonEncephalon DiseasesEnergy ExpenditureEnergy MetabolismEnergy Metabolism - Reference PathwayEnergy Metabolism PathwayEngineeringFDA approvedFaceGlucoseGlycolysisGoalsH2 isotopeHealthHomeostasisHumanImageImaging DeviceImaging InstrumentImaging ProceduresImaging TechnicsImaging TechniquesImaging ToolIntracellular Communication and SignalingIntracranial CNS DisordersIntracranial Central Nervous System DisordersIntratumoral heterogeneityKrebs CycleLeadershipLifeMR ImagingMR SpectroscopyMR TomographyMRIMRIsMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMalignant NeoplasmsMalignant TumorMapsMeasurementMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMental disordersMental health disordersMetabolicMetabolic PathwayMethodsMitochondriaModern ManMonitorMotorNMR ImagingNMR SpectrometerNMR SpectroscopyNMR TomographyNadideNerve CellsNerve UnitNervous System Degenerative DiseasesNervous System DiseasesNervous System DisorderNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeurologic DisordersNeurological DisordersNeuronsNeurosciences ResearchNicotinamide adenine dinucleotideNicotinamide-Adenine DinucleotideNoiseNuclearNuclear Magnetic Resonance ImagingO elementO2 elementOxidation-ReductionOxidative PhosphorylationOxidative Phosphorylation PathwayOxygenOxygen ConsumptionPathway interactionsPatientsPerformancePhosphorousPhosphorusPhysiologicPhysiologicalPhysiological HomeostasisPilot ProjectsPlayProcessProductionPsychiatric DiseasePsychiatric DisorderReactionRedoxResearchResearch DesignResearch ResourcesResolutionResourcesRoleScanningSignal TransductionSignal Transduction SystemsSignalingStrokeStudy TypeTCA cycleTechnologyTestingTimeTricarboxylic Acid CycleVisualZeugmatographyaerobic metabolismaerobic respirationaged brainaging brainaging processbiological signal transductionblood flow in brainbrain attackbrain blood circulationbrain blood flowbrain visualizationcerebralcerebral blood flowcerebral circulationcerebral vascular accidentcerebrocirculationcerebrovascular accidentcerebrovascular blood flowclinical applicabilityclinical applicationdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdetection sensitivityfacesfacialfacilities for imagingglucose metabolismheterogeneity in tumorshuman diseaseimage-based methodimagingimaging capabilitiesimaging centerimaging detectionimaging facilitiesimaging methodimaging modalityimaging-based detectionimaging-based disease detectionimaging-related facilitiesimprovedinnovateinnovationinnovativeinsightintra-tumoral heterogeneityintratumor heterogeneitykinetic modelmalignancymembermental illnessmetabolic imagingmetabolic ratemitochondrialneoplasm/cancerneural imagingneuro-imagingneurodegenerative illnessneuroimagingneurological diseaseneurological imagingneuronalneurophysiologicalneurophysiologynext generationnon-invasive imagingnoninvasive imagingnovelnuclear magnetic resonance spectroscopyoxidation reduction reactionoxidative metabolismpathwaypilot studypsychiatric illnesspsychological disorderquantitative imagingradio frequencyradiofrequencyresolutionsresponseskillssocial rolespatial and temporalspatial temporalspatiotemporalstrokedstrokesstudy designsuccesstemporal measurementtemporal resolutiontime measurementtooltranslational applicationstranslational studytreatment effecttumor heterogeneitytumors in the brain
Description preview
PROJECT SUMMARY
Cellular energy metabolism is a fundamental process of life that produces biochemical energy in the form of
adenosine triphosphate (ATP) to support neuronal activity and brain function. Glucose and oxygen are the
main energy substrates of the brain and are metabolized through glycolysis, the tricarboxylic acid cycle and
oxidative…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click