grant
Establishing the Function of TMEM184B in mTORC1 Regulation and Synaptic Maintenance
Organization UNIVERSITY OF ARIZONALocation TUCSON, UNITED STATESPosted 1 Jul 2018Deadline 30 Nov 2028
NIHUS FederalResearch GrantFY2026AffectAmino AcidsAssayBehaviorBile AcidsBioassayBiochemicalBiological AssayCNS plasticityCRISPRCRISPR/Cas systemCatabolismCausalityCell BodyCell Communication and SignalingCell SignalingCellsCellular AssayChildhoodClassificationClustered Regularly Interspaced Short Palindromic RepeatsCorpus CallosumCorpus CallosumsDNA mutationDataDefectDevelopmentDiagnosisDiseaseDisorderDrosophilaDrosophila genusElectrophysiologyElectrophysiology (science)EndosomesEnsureEpilepsyEpileptic SeizuresEpilepticsEtiologyFK506 Binding Protein 12-Rapamycin Associated Protein 1FKBP12 Rapamycin Complex Associated Protein 1FRAP1FRAP1 geneFRAP2FliesGeneralized GrowthGenesGeneticGenetic ChangeGenetic defectGenetic mutationGlutamatesGoalsGrowthHumanHyperactivityImpairmentIn vivo analysisIntellectual disabilityIntellectual functioning disabilityIntellectual limitationIntracellular Communication and SignalingIntracellular MembranesKnowledgeL-GlutamateLifeLinkLipidsMaintenanceMechanistic Target of RapamycinMediatingMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMiceMice MammalsMicrocephalyModelingModern ManMolecularMorphologyMurineMusMutant Strains MiceMutationMyoneural JunctionNerveNerve CellsNerve UnitNervous SystemNervous System DiseasesNervous System DisorderNeural CellNeural DevelopmentNeural TransmissionNeurocyteNeurologicNeurologic Body SystemNeurologic DeficitNeurologic DisordersNeurologic Organ SystemNeurologicalNeurological DisordersNeuromuscular JunctionNeuronal PlasticityNeuronsNeurophysiology / ElectrophysiologyPathway interactionsPatientsPhenotypeProcessProteinsProteomicsPublishingRAFT1ReceptosomesRegulationRoleSeizure DisorderSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSterolsStructureSurface ProteinsSwellingSynapsesSynapticSynaptic TransmissionSynaptic VesiclesSyndromeSystematicsTestingThermodynamicThermodynamicsTissue GrowthVariantVariationWorkaminoacidbehavior phenotypebehavioral phenotypingbiological signal transductioncausationcell assaycentral nervous system plasticitydevelopmentaldisease causationelectrophysiologicalendosome membraneepilepsiaepileptogenicflyfruit flygenome mutationglutamatergichuman diseasehuman modelimprovedin silicoin vivoin vivo evaluationin vivo testinginsightintellectual and developmental disabilitylimited intellectual functioninglipidomicsmTORmalformationmammalian target of rapamycinmicrencephalymicroencephalymodel of humanmouse mutantneural plasticityneurodevelopmentneurological diseaseneuronalneuronal growthneuroplasticneuroplasticitynovelontogenypathwaypediatricphospho-proteomicsphosphoproteomicsprotein structureprotein structuresproteins structurerestorationsocial rolesynapsesynapse formationsynaptogenesisthermolabilitythermostabilitytooltumor
Description preview
Synaptic disruption is a prelude to and often a primary cause of neurological disease, but we have few
strategies to correct dysmorphic synapses, even if they occur early in the degenerative process. Growth
control pathways, i.e. those that promote protein and lipid synthesis while reducing catabolism, regulate
synaptic form that in turn ensures…
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