grant
Establishing Combinatorial Screening Platform Coupled to Single-cell Analysis
Organization DIVISION OF BASIC SCIENCES - NCILocation UNITED STATES
NIHUS FederalResearch GrantFY2025AblationAbscissionAlternate SplicingAlternative RNA SplicingAlternative SplicingBinding SitesBiological FunctionBiological ProcessCRISPR editing screenCRISPR screenCRISPR-based screenCRISPR/Cas9 screenCell BodyCellsCombining SiteCoupledDataDiseaseDisorderExcisionExonsExpression SignatureExtirpationGene ExpressionGene Expression ProfileGene TranscriptionGenesGeneticGenetic TranscriptionGuide RNAHumanIndividualLibrariesModern ManOutputPhenotypePlayPoly APoly(rA)PreparationProteomicsProtocolProtocols documentationRNA ExpressionRNA SplicingReactive SiteRemovalResolutionRoleSplicingSurgical RemovalSystemTechnologyTherapeutic InterventionTranscriptTranscriptionVariantVariationclustered regularly interspaced short palindromic repeats screencombinatorialcost effectiveexperimentexperimental researchexperimental studyexperimentsexpression vectorgRNAgene expression patterngene expression signaturegene functiongenetic elementgenome editinggenomic editinginsightintervention therapyloss of functionnovelnucleasepolyadenylatepreparationsresectionresolutionsscRNA sequencingscRNA-seqscaffoldscaffoldingscreeningscreeningssingle cell RNA-seqsingle cell RNAseqsingle cell analysissingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial roletherapeutic candidatetooltranscriptional profiletranscriptional signaturetranscriptomics
Description preview
By optimizing the hgRNA scaffold sequence and refining library preparation protocols, we have significantly enhanced the CHyMErA exon deletion screening platform for single-cell experiments. This advanced tool enables efficient combinatorial genetic perturbations and precise gene segment deletions, while uniquely supporting the simultaneous…
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