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Establishing a Single-Cell Proteomic Atlas for Normal and Osteoarthritic Articular Cartilage

Organization STANFORD UNIVERSITYLocation STANFORD, UNITED STATESPosted 17 May 2021Deadline 31 Mar 2026 ⚠️
NIHUS FederalResearch GrantFY2025AblationAccelerationAffectAnimal ModelAnimal Models and Related StudiesAnimalsAntibodiesArthroplastyAtlasesAutoregulationBody TissuesCartilageCartilage DiseasesCartilaginous TissueCell BodyCell-Extracellular MatrixCellsChondrocytesClinical TrialsCytometryDataDegenerative ArthritisDegenerative polyarthritisDetectionDiseaseDisease ProgressionDisorderDrug TherapyDrugsECMEncapsulatedEventExtracellular MatrixFailureGoalsHeterogeneityHomeostasisHumanI-kappa BI-kappa B ProteinsIKBIn SituIndividualInflammationInflammatoryJoint Prosthesis ImplantationJointsKnowledgeLabelMapsMedicalMedicationModern ManMolecularNF-Kappa B InhibitorNFKB InhibitorOsteoarthritisOsteoarthrosisPain ControlPain TherapyPain managementPathogenesisPathogenicityPathologicPathologyPathway interactionsPatientsPharmaceutical PreparationsPharmacological TreatmentPharmacotherapyPhysiological HomeostasisPopulationProteinsProteomicsPublishingRNA SeqRNA sequencingRNAseqRare Earth MetalsReceptor ProteinReplacement ArthroplastyReportingResearchResearch ResourcesResolutionResourcesSamplingScienceSignal PathwayStaining methodStainsTechniquesTechnologyTestingTherapeuticTissue EngineeringTissuesTraumatic ArthritisTraumatic Arthropathyarticular cartilagebioengineered tissuecartilage disordercartilage regenerationcartilage repaircell typecohortdegenerative joint diseasedrug candidatedrug developmentdrug interventiondrug treatmentdrug/agentengineered tissuehypertrophic arthritisinflammation markerinflammatory markerinflammatory modulationinhibitorinsightjoint arthroplastyjoint replacementmodel of animalmouse modelmurine modelnovelpain interventionpain treatmentpathwaypharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspost-traumatic osteoarthritispre-clinicalpreclinicalrare earth elementreceptorregeneration potentialregenerativeregenerative cellregenerative potentialresolutionsresponsescRNA sequencingscRNA-seqsenescencesenescentsenescent cellsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsmall molecular inhibitorsmall molecule inhibitorsuccesstherapeutic evaluationtherapeutic testingtranscriptome sequencingtranscriptomic sequencingtranscriptomics

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Description preview

Abstract
Although multiple pathways and targets have been proposed for OA treatment, the rate of drug failure in clinical
trials has been astoundingly high. The reasons for the limited success include the late detection of the disease
and a lack of understanding of the molecular heterogeneity between patients. In this proposal, we aim to…

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