grant
Erythroblastic island macrophages in normal erythropoiesis and disordered erythropoiesis in polycythemia vera
Organization NEW YORK BLOOD CENTERLocation NEW YORK, UNITED STATESPosted 1 Aug 2025Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY2026AnemiaBiologyBlood DiseasesBlood erythrocyteC-KIT GeneCD117CD117 AntigensCD71Cell Communication and SignalingCell Cycle Regulation PathwayCell SignalingChemicalsCo-cultureCocultivationCocultureCoculture TechniquesDNA mutationDevelopmentDiseaseDisorderEPOREPOR geneEnlarged SpleenErythremiaErythroblastsErythrocytesErythrocyticErythrocytosesErythroidErythroid CellsErythroid Precursor CellsErythroid Progenitor CellsErythroid Stem CellsErythropoiesisErythropoietic Progenitor CellsErythropoietic Stem CellsErythropoietin Receptor GeneExhibitsFe elementGene DeletionGenesGenetic ChangeGenetic defectGenetic mutationGrowth AgentsGrowth FactorGrowth SubstancesHematologic DiseasesHematological DiseaseHematological DisorderHemoglobinHumanHuman CharacteristicsHuman NatureImpairmentIn TransferrinIn VitroIntracellular Communication and SignalingIronIslandJAK-2JAK2JAK2 geneJAK2 proteinJanus kinase 2KITLGKITLG geneKL-1KO miceKit Ligand GeneKitlKnock-inKnock-out MiceKnockout MiceLeadMacrophageMarrow erythrocyteMast Cell Growth Factor ReceptorMediatingMiceMice MammalsModern ManMolecularMurineMusMutationMφNormoblastsNucleated ErythrocytesNucleated red blood cellNucleated red cellNull MouseOsler-Vaquez DiseasePathogenesisPatientsPb elementPhosphorylationPlayPolycythemia Rubra VeraPolycythemia VeraProductionProliferatingProtein PhosphorylationProteins Growth FactorsProto-Oncogene Protein c-kitProtocolProtocols documentationRed Blood CellsRed CellRed PulpRoleSCF ReceptorSCF Receptor GeneSCFRSiderophilinSignal TransductionSignal Transduction SystemsSignalingSpleenSpleen Reticuloendothelial SystemSplenic Red PulpSplenomegalyStem Cell Factor ReceptorStem Cell Factor Receptor GeneSystemTFR geneTFR proteinTFR1TFRCTFRC geneTRFRTestingTransferrinTransferrin ReceptorTransferrin Receptor 1Tumor CellTyrosine-Protein Kinase JAK2Upregulationbiological signal transductionblood corpusclesblood disorderc kitc-kit Proteinc-kit Receptorconditional knock-outconditional knockoutdevelopmentalerythroid developmenterythroid progenitorerythroid-committed progenitorsgene deletion mutationgenome mutationheavy metal Pbheavy metal leadimprovedin vivoinhibitorinsightkit Proto-Oncogene Proteinknock-downknockdownknockinmicrocytic anemiamouse modelmurine modelneoplastic cellnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeutic targetnew therapy approachesnew therapy targetnew treatment approachnew treatment strategynovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeutic targetnovel therapy approachnovel therapy targetnucleated RBCsp145(c-kit)p145c-kitsocial role
Description preview
ABSTRACT
Erythropoiesis occurs at the erythroblastic island where the central macrophage (EBI M) supports proliferation
and maturation of the surrounding erythroid cells. Alterations in EBI M contribute to the disordered
erythropoiesis in various hematological diseases including polycythemia vera (PV) which is characterized by
erythrocytosis due…
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