grant
ER and post-ER quality control of integral membrane proteins
Organization UNIVERSITY OF PITTSBURGH AT PITTSBURGHLocation PITTSBURGH, UNITED STATESPosted 1 Jun 2019Deadline 31 May 2029
NIHUS FederalResearch GrantFY202526 S proteasome complex26S ATP-Dependent Protease26S ATP-Dependent Proteasome26S Proteasome Complex26S Proteosome26S protease26S proteasomeAddressAmino AcidsBiologic ModelsBiological ModelsCausalityCell BodyCellsCellular biologyChargeChemicalsCollaborationsCommunitiesCytoplasmCytosolDNA mutationDedicationsDegradation PathwayDegradative PathwayDiseaseDisorderEndoplasmic ReticulumEnvironmentErgastoplasmEtiologyFaceGene AlterationGene MutationGenerationsGenesGenetic ChangeGenetic defectGenetic mutationGoalsHereditaryHumanIndividualInheritedIntegral Membrane ProteinIntrinsic Membrane ProteinIon ChannelIon TransportIonic ChannelsKnowledgeLinkMembraneMembrane ChannelsMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMethodsModel SystemModelingModern ManMolecularMutationNamesPathway interactionsProtein BiosynthesisProtein TraffickingQuality ControlResearchRibosomal Peptide BiosynthesisRibosomal Protein BiosynthesisRibosomal Protein SynthesisSideSurface ProteinsTM DomainTechniquesToxic effectToxicitiesTranslatingTransmembrane DomainTransmembrane ProteinTransmembrane Protein GeneTransmembrane RegionUbiquitilationUbiquitinationUbiquitinoylationVariantVariationaberrant folded proteinaberrant folded proteinsabnormal folded proteinabnormal folded proteinsaminoacidcausationcell biologydisease causationfacesfacialgene defectgenome mutationhydrophilicityinnovateinnovationinnovativeloss of functionmembrane structuremisfolded proteinmisfolded proteinsmutant allelenamenamednamingnon-Nativenonnativenovelpathwaypersonalization of treatmentpersonalized medicinepersonalized therapypersonalized treatmentposterspreventpreventingprotein foldingprotein synthesisprotein transportproteotoxic proteinproteotoxinreconstitutereconstitutionsolutetooltraffickingubiquinationubiquitin conjugation
Description preview
Approximately one-quarter of all proteins synthesized in human cells integrate into the membrane of the
endoplasmic reticulum (ER) as they are translated. However, membrane protein folding is problematic. First,
structurally diverse integral membrane proteins face the challenge of folding co-translationally and post-
translationally in three…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click