grant
Epitranscriptomic and Epigenetic Loops Driving the Response to Naphthalene
Organization STATE UNIVERSITY OF NEW YORK AT ALBANYLocation ALBANY, UNITED STATESPosted 1 Apr 2026Deadline 31 Mar 2031
NIHUS FederalResearch GrantFY20262'-deoxy-cytidineActive OxygenAcuteAromatic Polycyclic HydrocarbonsAssayAutomobile DrivingBasal Transcription FactorBasal transcription factor genesBenzeneBenzolBenzoleBioassayBiological AssayBiological MarkersBiologyBloodBlood Reticuloendothelial SystemBlood SampleBlood specimenBronchioalveolar LavageBronchoalveolar LavageBronchopulmonary LavageCarcinogen-DNA AdductsCell BodyCell FunctionCell PhysiologyCell ProcessCell modelCellsCellular FunctionCellular PhysiologyCellular ProcessCellular StressCellular Stress ResponseCellular modelCodonCodon NucleotidesCyclohexatrieneCytosine DeoxyribonucleosideCytosine DeoxyribosideDNADNA AdductsDNA DamageDNA InjuryDNA MethylationDNA methylation profilingDataData SetDeoxycytidineDeoxyribonucleic AcidDetectionDrug Metabolic DetoxicationDrug Metabolic DetoxificationEmbryoEmbryonicEngineeringEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExerciseExposure toFibroblastsFire - disastersFiresGene ExpressionGene FamilyGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic TranscriptionGoalsH2O2HarvestHealthHeavy MetalsHistopathologyHumanHydrogen PeroxideHydroperoxideIn VitroLinkLiverLungLung InflammationLung LavageLung Respiratory SystemMessenger RNAMetabolic Drug DetoxicationsMetabolism of Toxic AgentsMethodsMethyl-SeqMethylSeqMethylation sequencingMiceMice MammalsModern ManModificationMurineMusNaphthaleneNon-Polyadenylated RNAOxygen RadicalsPatternPhenotypePneumonitisPolyribosomesPolysomesPro-OxidantsProteomicsPublishingPulmonary InflammationRNARNA ExpressionRNA Gene ProductsReaction TimeReactive Oxygen SpeciesRegulationReporterResponse RTResponse TimeRibonucleic AcidRibosomesSmokeStressSubcellular ProcessSystemTechnologyTestingToxic effectToxicant exposureToxicitiesTrainingTranscriptTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTransfer RNATranslational RegulationTranslationsTriplet Codon-Amino Acid AdaptorVolatilizationbio-markersbiologic markerbiological adaptation to stressbiomarkerbisulfitebronchiolar alveolar lavagebronchopulmonary lavage therapycell stresschromatin remodelingcohortdetoxificationdrivingepigeneticallyepigenomeepitranscriptomeepitranscriptomicsfirefire fighterfire servicesfirefighterfrontierhepatic body systemhepatic organ systemhuman datahydrogen sulfitehydrosulfitein vivoinsightmRNAmRNA Translationmouse modelmurine modelnovelpolyaromatic hydrocarbonspolynuclear aromatic hydrocarbonprogramspsychomotor reaction timereaction; crisisrespiratoryresponseselenoproteinsmoke inhalationstress responsestress; reactiontRNAtoxic exposuretoxicanttranscription factortransfer Ribonucleic acidstranslationwood smokewoodsmoke
Description preview
1. PROJECT SUMMARY
The goal of the proposed studies is to define the interplay between the epitranscriptome and the epigenome in
regulating cellular responses to toxicants, focusing on the respiratory toxicant naphthalene (NA) as one of the
most abundant components of wood smoke. Epi-marks in the form of DNA-based epigenetic modifications that…
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