grant
Epithelial biology: morphogenesis and damage signaling
Organization UNIVERSITY OF CALIFORNIA BERKELEYLocation BERKELEY, UNITED STATESPosted 1 Jan 2019Deadline 28 Feb 2029
NIHUS FederalResearch GrantFY2025(TNF)-α21+ years oldAddressAdultAdult HumanAnimalsArchitectureAutoregulationBasement membraneBiochemicalBiologyBirth DefectsBody TissuesCachectinCell Communication and SignalingCell SignalingCell-Extracellular MatrixChronicCollaborationsCommunicationCongenital AbnormalityCongenital Anatomical AbnormalityCongenital DefectsCongenital DeformityCongenital MalformationDefectDevelopmentDiseaseDisorderDistantDrosophilaDrosophila genusECMEngineering / ArchitectureEpitheliumExtracellular MatrixFoundationsFundingGeneticGoalsHealthHomeostasisImageImmune responseInflammationInjuryIntracellular Communication and SignalingInvestigationKnowledgeLaboratoriesMacrophage-Derived TNFMechanicsMediatingMonocyte-Derived TNFMorphogenesisMovementNIGMSNational Institute of General Medical SciencesNormal TissueNormal tissue morphologyOrganPathologyPathway interactionsPatternPhylogenyPhysiological HomeostasisResearchResistanceShapesSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSignaling MoleculeSterilityTNFTNF ATNF AlphaTNF geneTNF-αTNFATNFαTechniquesTissuesTransmissionTumor Necrosis FactorTumor Necrosis Factor-alphaWorkadulthoodanti-microbialantimicrobialbiological signal transductionbody movementcell typedevelopmentalempowermentepithelial injuryexperimentexperimental researchexperimental studyexperimentsfruit flyhost responseimagingimmune system responseimmunoresponseinjuriesmechanicmechanicalmechanical propertiesmorphogenetic processmultidisciplinarypathwayprogramsresistantresponsesteriletissue repairtransmission processwound response
Description preview
PROJECT SUMMARY
Epithelia are the core cell type of animals, and constitute the most widespread and ancient mode of tissue
architecture. My lab uses a distinctive set of multidisciplinary strategies to study fundamental questions of
epithelial biology using Drosophila, leveraging deep evolutionary conservation to uncover general principles…
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