grant
Epigenetic regulation of intestinal tuft cells
Organization CINCINNATI CHILDRENS HOSP MED CTRLocation CINCINNATI, UNITED STATESPosted 1 Aug 2024Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025AnimalsAutoregulationBiologyButyratesCalibrationCell BodyCell Communication and SignalingCell CountCell DifferentiationCell Differentiation processCell FunctionCell LineageCell NumberCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessCellular biologyChromatinComplexCrohn diseaseCrohn'sCrohn's diseaseCrohn's disorderDataDevelopmentDiseaseDisorderEnzyme GeneEnzymesEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEpithelial CellsEpitheliumGI Stem cellGI commensalGI microbiotaGastrointestinal microbiotaGene TranscriptionGeneticGenetic TranscriptionGnotobioticGnotobioticsGoalsGranulomatous EnteritisHDAC AgentHDAC inhibitorHDAC3HDAC3 enzymeHDAC3 geneHealthHistone Deacetylase InhibitorHistone deacetylase inhibitionHomeostasisHumanImmuneImmune responseImmunesImmunityInflammationInflammatory Bowel DiseasesInflammatory Bowel DisorderInnate Immune ResponseInositol PhosphatesIntestinalIntestinal DiseasesIntestinal DisorderIntestinesIntracellular Communication and SignalingLinkMediatingMiceMice MammalsModelingModern ManMurineMusOrganoidsPathogenesisPathologicPathway interactionsPatientsPersonalized medical approachPhysiological HomeostasisPlayPredispositionProgenitor CellsPublic HealthPublishingRNA ExpressionRPD3-2RegulationRoleSeveritiesSignal TransductionSignal Transduction SystemsSignalingSpecialized Epithelial CellStimulusSubcellular ProcessSusceptibilityTestingTranscriptionTransgenic OrganismsUlcerated ColitisUlcerative ColitisWorkactive controladaptive immune responsebiological signal transductionbowelbowel inflammationcell biologycell typecellular differentiationcommensal bacteriacommensal bacteria in the gastrointestinal tractcommensal bacteria in the gutcommensal bacteria in the intestinecommensal bacterial speciescommensal floracommensal microbescommensal microbiotacommensal microfloradevelopmentaleleocolitisenteric commensalenteric microbial communityenteric microbiotaepigenetic regulationepigeneticallygain of functiongastrointestinal commensalgastrointestinal homeostasisgastrointestinal microbial floragastrointestinal stem cellgut commensalgut communitygut floragut inflammationgut microbe communitygut microbial communitygut microbial compositiongut microbial consortiagut microbiotagut microbioticgut microfloragut progenitorgut stem cellhistone deacetylase 3histone modificationhost microbiotahost microflorahost responseimmune system responseimmunoresponseimprovedin vivoindividualized approachinflamed bowelinflamed gutinflamed intestineinflammatory disease of the intestineinflammatory disorder of the intestineintestinal autoinflammationintestinal commensalintestinal epitheliumintestinal floraintestinal homeostasisintestinal inflammationintestinal microbiotaintestinal microfloraintestinal progenitorintestinal stem cellsintestinal tract microfloraintestine diseaseintestine disorderloss of functionmicrobialmicrobial consortiamicrobial floramicrobiotamicrobiota derived metabolitesmicrobiota metabolitesmicrofloramouse modelmultispecies consortiamurine modelnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachnutrient absorptionpathwaypersonalized approachprecision approachpreventpreventingprogenitor cell differentiationprogenitor differentiationregional enteritisresident microbesresident microfloraresponsesensorsocial rolestemstem and progenitor differentiationstem cell differentiationstem cellstailored approachtooltransgenicvillin
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Description preview
Intestinal epithelial cells reside at the direct interface between the microbiota and mammalian
host, and are thus uniquely poised to sense microbial signals that calibrate intestinal immunity
and function. Tuft cells are a specialized epithelial cell that have recently been shown to respond
to microbial stimuli and initiate and amplify type 2…
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