grant
Epigenetic Regulation and Function of Imprinted Genes
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 1 Apr 2026Deadline 31 Mar 2031
NIHUS FederalResearch GrantFY2026ASM1AffectAllelesAllelomorphsArchitectureBeckwith syndromeBeckwith-Wiedemann SyndromeBindingCancersCell LineCellLineD11S813EDNADNA MethylationDNA mutationDefectDeoxyribonucleic AcidDependenceDevelopmentDiseaseDisorderEngineering / ArchitectureEnzyme GeneEnzymesEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExhibitsExomphalos-Macroglossia-Gigantism SyndromeFemaleFertilizationFunctional RNAGametesGene ExpressionGene ModifiedGenesGeneticGenetic ChangeGenetic ImprintingGenetic defectGenetic mutationGenomeGenomic ImprintingGerm CellsGerm LinesGerm-Line CellsGestationH19H19 geneHumanMGC4485MaintenanceMalignant NeoplasmsMalignant TumorMammaliaMammalsMediatingMethylationMiceMice MammalsModern ManModificationMolecular InteractionMurineMusMutationNoncoding RNANontranslated RNANuclearParental ImprintingParentsPregnancyProcessProductionProteinsRegulationReproductive CellsRoleRussell dwarfRussell nanismRussell syndromeRussell-Silver dwarfismSex CellSilver-Russell syndromeStrains Cell LinesSyndromeTransmissionUntranslated RNAVariantVariationWiedemann syndromeWiedemann-Beckwith-Combs syndromeWorkcultured cell linedemethylationdevelopmentaldosageepigenetic regulationepigeneticallyexomphalos-macroglossia-gigantism (EMG) syndromefamilial macroglossia-omphalocele syndromefertilizationsgene functiongene modificationgenetically modifiedgenome mutationimprintin vivoinitial cellmacroglossia-omphalocele syndromemacroglossia-omphalocele-visceromegaly syndromemalemalignancymammalian genomemutantneoplasm/cancernoncodingoffspringoxidationparentsexsexual cellsocial roletransmission process♀♂
Description preview
Abstract
A few hundred genes in mammals are regulated by genomic imprinting. These genes are epigenetically
marked and exhibit parental-of-origin-specific gene expression. Imprinting plays a role in the transmission of a
number of human disorders, including Beckwith-Wiedemann Syndrome and Silver-Russell Syndrome, where
the sex of the parent…
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