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Epigenetic modulation of CD4+ T cell differentiation and autoimmunity by trichloroethylene

Organization UNIVERSITY OF NEW MEXICO HEALTH SCIS CTRLocation ALBUQUERQUE, UNITED STATESPosted 15 Apr 2021Deadline 31 Dec 2025 ⚠️
NIHUS FederalResearch GrantFY2025Adoptive TransferAutoimmuneAutoimmune DiseasesAutoimmune StatusAutoimmunityBS-seqBisulfite-based sequencingBody TissuesCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCell BodyCell DifferentiationCell Differentiation processCellsChemicalsChronicControl GroupsDNA MethylationDermalDifferentiation in cell cultureDiseaseDisorderEffector CellEnvironmental PollutantsEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEthinyl TrichlorideEventExposure toFemaleFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryGene ExpressionGenesGenetic PredispositionGenetic Predisposition to DiseaseGenetic SusceptibilityGenetic propensityGoalsGrantHalf-LifeHumanHydrationHydration statusHypersensitivityIFNImmuneImmune DiseasesImmune DisordersImmune DysfunctionImmune System DiseasesImmune System DisorderImmune System DysfunctionImmune System and Related DisordersImmune responseImmunesImmunologic DiseasesImmunological DiseasesImmunological DysfunctionImmunological System DysfunctionIn VitroIn vitro cell differentiationIndividualIndustrializationInflammatoryInherited PredispositionInherited SusceptibilityInterferonsIntermediary MetabolismKnowledgeLiquid substanceLupusMediatingMemoryMetabolic ProcessesMetabolismMethylationMiceMice MammalsModern ManMouse StrainsMurineMusNatureOutcomePathogenicityPathologyPathway interactionsPreventionProcessProductionPromoter RegionsPromotor RegionsProteinsPublic HealthRNA SeqRNA sequencingRNAseqResearchResistanceRisk FactorsSolventsT cell differentiationT-Cell ActivationT-CellsT-LymphocyteT4 CellsT4 LymphocytesTestingTimeTissuesTrichloroetheneTrichloroethyleneVariantVariationactivate T cellsautoimmune conditionautoimmune disorderautoimmunity diseasebisulfite sequencingbisulfite-seqcellular differentiationchloralcomparing females and malescomparing women and mencytokinedifferentiation in culturedifferentiation in vitrodisease riskdisorder riskdrinking waterenvironmental chemicalenvironmental contaminantepigeneticallyexperimentexperimental researchexperimental studyexperimentsfemales compared to malesfemales compared with malesfemales versus malesfemales vs. malesflow cytophotometryfluidgene signaturesgenetic etiologygenetic mechanism of diseasegenetic promoter elementgenetic promoter sequencegenetic signaturegenetic vulnerabilitygenetically predisposedgenome scalegenome-widegenomewidehost responseimmune system responseimmunoresponsein vitro cellular differentiationin vivoinhibitorinnovateinnovationinnovativeinsightliquidlupus cutaneouslupus prone micelupus-likemalememory CD4 T cellmemory CD4 T lymphocytemethylation patternnovelpathwaypromoter sequenceresistantsexsuperfund sitetargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmentthymus derived lymphocytetranscriptome sequencingtranscriptomic sequencingtrichloro-ethenetrichloroacetaldehydewater solubilitywomen compared to menwomen compared with menwomen versus menwomen vs. men♀♂

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Description preview

PROJECT SUMMARY
Studies to delineate the autoimmune-promoting effects of the environmental pollutant, trichloroethylene (TCE),
have focused on functional effects in effector/memory CD4+ T cells from lupus-prone mice. Our long-term goal
is to understand how TCE drives CD4 cell differentiation to promote autoimmunity and/or hypersensitivity…

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