grant
Epigenetic mechanisms of positive affective state of AUD
Organization UNIVERSITY OF ILLINOIS AT CHICAGOLocation Chicago, UNITED STATESPosted 3 Jun 2025Deadline 31 May 2030
NIHUS FederalResearch GrantFY2025(IFN) α(IFN)-α(IFN)α3-D3-Dimensional3D4-Aminobutanoic Acid4-Aminobutyric Acid4-amino-butanoic acid5 AZC5-AC5-Aza-cytidine5-AzacytidineAOF2ATAC sequencingATAC-seqATACseqAZCAcetylationAffectAffectiveAlcohol Chemical ClassAlcohol abuseAlcohol withdrawal syndromeAlcoholsAlferonAminalonAminaloneAmmon HornAmygdalaAmygdaloid BodyAmygdaloid NucleusAmygdaloid structureAnxietyAreaAssayAssay for Transposase-Accessible Chromatin using sequencingAstrocytesAstrocytusAstrogliaAttenuatedAutopsyAzacitidineAzacytidineBehaviorBehavior-Related DisorderBehavior-Related ProblemBehavioralBioassayBiologicalBiological AssayBody TissuesBrainBrain Nervous SystemBrain regionCRISPRCRISPR/Cas systemCell BodyCellsChIP assayCholesterolChromatinClustered Regularly Interspaced Short Palindromic RepeatsCommon Rat StrainsCornu AmmonisDNA MethylationDNA Methyltransferase InhibitorDevelopmentDietDifferential Gene ExpressionDiseaseDisorderDown-RegulationE1A Binding Protein p300ENX-1EP300EP300 geneEZH1EZH2EZH2 geneElectron MicroscopyElectrophysiologyElectrophysiology (science)EncephalonEnhancer of Zeste 2 Polycomb Repressive Complex 2 SubunitEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEquilibriumEtOH abuseExhibitsFemaleGABAGene ClusterGene Down-RegulationGene ExpressionGene Expression AlterationGenesGenomicsGoalsGuide RNAHDAC AgentHDAC inhibitorHealth Care CostsHealth CostsHippocampusHistone Deacetylase InhibitorHistone deacetylase inhibitionHortega cellHumanIFN AlphaIFN αIFN-αIFNaIFNαImmune PrecipitationImmunofluorescenceImmunofluorescence ImmunologicImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodImmunoprecipitationIn VitroInterferon Alfa-n3Interferon-αKAT3BKDM1AKDM1A geneKMT6KMT6AKnowledgeLSD1LentivirinaeLentivirusLeukocyte InterferonLifestyle-Related DisorderLifestyle-Related ProblemLifestyle-related conditionLymphoblast InterferonLymphoblastoid InterferonLysine-Specific Demethylase 1Lysine-Specific Demethylase 1AMeasuresMethodsMethylationMicrogliaModern ManModificationMolecularMorphologyMotivationNerve CellsNerve UnitNeural CellNeurocyteNeuroimmuneNeuroimmune systemNeuronsNeurophysiology / ElectrophysiologyNucleus AccumbensPathway interactionsPhenotypePhysiologyPrefrontal CortexPreventionRNA SeqRNA sequencingRNAseqRatRats MammalsRattusRecoveryRegulationRelapseRewardsRoleSelf StimulationSingle-Nucleus SequencingStaining methodStainsStructureSymptomsSynapsesSynapticTechniquesTestingTissue-Specific Differential Gene ExpressionTissue-Specific Gene ExpressionTissuesTranscription RepressionUpregulationVentral Tegmental AreaWithdrawalalcohol co-abusealcohol cravingalcohol exposedalcohol exposurealcohol problemalcohol related researchalcohol researchalcohol seekingalcohol seeking behavioralcohol use disorderalcohol withdrawalamygdaloid nuclear complexantagonismantagonistassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingastrocytic gliaattenuateattenuatesbalancebalance functionbehavior phenotypebehavioral phenotypingbiologiccell typechromatin immunoprecipitationchronic EtOH drinkingchronic alcohol consumptionchronic alcohol drinkingchronic alcohol ingestionchronic alcohol usechronic ethanol consumptionchronic ethanol drinkingchronic ethanol ingestioncostdevelopmentaldietsdifferential expressiondifferentially expressedeffective therapyeffective treatmentelectrophysiologicalentire genomeenzyme pathwayepigenetic regulationepigeneticallyepigenomicsethanol abuseethanol cravingethanol exposedethanol exposureethanol researchethanol seekingethanol use disorderethanol withdrawalethanol-seeking behaviorexperimentexperimental researchexperimental studyexperimentsexposed to alcoholexposed to ethanolexposure to alcoholexposure to ethanolfull genomegRNAgamma-Aminobutyric Acidgene manipulationgene repressiongenetic manipulationgenetically manipulategenetically perturbgenome sequencinggitter cellglobal gene expressionglobal transcription profilehazardous alcohol usehippocampalhistone acetyltransferase p300inhibitorinsightladakamycinmalemesogliamicroglial cellmicrogliocytenecropsyneural adaptationneuroadaptationneuronalnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyp300pathwayperivascular glial cellpharmacologicpostmortempreventpreventingproblem alcohol useproblem drinkingproblematic alcohol consumptionproblematic alcohol usepromoterpromotorsNuc-SeqshRNAshort hairpin RNAsingle nucleus RNA-sequencingsingle nucleus seqsingle-nucleus RNA-seqsmall hairpin RNAsnRNA sequencingsnRNA-seqsocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicssynapsethree dimensionaltranscriptional differencestranscriptometranscriptome sequencingtranscriptomic sequencingtranscriptomicsventral tegmentumwhole genomewithdrawal from alcoholγ-Aminobutyric Acid♀♂
Description preview
Project Summary/Abstract
The withdrawal syndrome of alcohol use disorder (AUD) includes both negative symptoms, like
anxiety, and motivational symptoms such as craving for alcohol, which promotes relapse and
alcohol seeking. Understanding how alcohol withdrawal changes brain physiology is an important
step towards developing effective treatments…
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