grant
Epigenetic Control of High Confidence Autism Spectrum Disorder Genes
Organization HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCESLocation EAST LANSING, UNITED STATESPosted 1 Apr 2026Deadline 31 Jan 2031
NIHUS FederalResearch GrantFY20261st trimester20p122nd trimesterASDAir PollutantsAir PollutionAutismAutistic DisorderAutopsyBehavioralBiologicalBrainBrain Nervous SystemCell BodyCell LineCellLineCellsCerebrumChromosomesComplexConfocal MicroscopyDNA HelicasesDNA Unwinding ProteinsDNA mutationDNA unwinding enzymeDNA-Binding ProteinsDataDepakoteDepakote ERDevelopmentDiagnosisDivalproexDoseEarly Infantile AutismEarly Placental PhaseEcologic MonitoringEcological MonitoringEcological impactElementsEncephalonEnvironmental ExposureEnvironmental FactorEnvironmental ImpactEnvironmental MonitoringEnvironmental Risk FactorEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEpistasisEpistatic DeviationFamilyFemaleFirst Pregnancy TrimesterFirst TrimesterFunctional RNAGWA studyGWASGene ExpressionGene InactivationGene SilencingGene TranscriptionGene variantGene x Environment InteractionGenesGeneticGenetic ChangeGenetic EpistasisGenetic RiskGenetic TranscriptionGenetic defectGenetic mutationGenetic predisposing factorGenotypeGoalsGxE interactionHarvestHealth CareHeritabilityHumanIndividualInduced DNA AlterationInduced MutationInduced Sequence AlterationInfantile AutismInteraction DeviationInterventionKanner's SyndromeKnowledgeLinkMidtrimesterModelingModern ManMolecularMolecular TargetMutant Strains MiceMutationNeural DevelopmentNeural Stem CellNeurodevelopmental DisorderNeurological Development DisorderNeuronal DifferentiationNoncoding RNANontranslated RNAOrganoidsOutcomePM2.5PaperParticulate MatterPathway interactionsPhenotypePhysiologyPrevalencePublishingRNA ExpressionResearchRisk FactorsRisk-associated variantSecond Pregnancy TrimesterSecond TrimesterStrains Cell LinesSymptomsSynapsesSynapticTestingTherapeutic AgentsTimeTranscriptionTransfectionUntranslated RNAValproic Acidallelic variantassess effectivenessautism spectral disorderautism spectrum disorderautistic individualsautistic peopleautistic spectrum disorderbiologiccell typecerebralcritical periodcultured cell linederepressiondesigndesigningdetermine effectivenessdevelopmentaldisease riskdisorder riskeffectiveness assessmenteffectiveness evaluationenvironment effect on geneenvironmental riskenvironmental testingepidemiology research studyepidemiology studyepidemiology surveyepigeneticallyepistatic interactionepistatic relationshipevaluate effectivenessexamine effectivenessexome sequencingexome-seqexperimentexperimental researchexperimental studyexperimentsexposed human populationexposure to environmental agentsexposure to environmental factorsexposure to environmental stimuliexposure to environmental substancesfine particlesfine particulate matterflexibilityflexiblefunctional genomicsgene environment interactiongene x gene interactiongenetic epistasesgenetic risk factorgenetic variantgenome mutationgenome scalegenome wide associationgenome wide association scangenome wide association studygenome-widegenomewidegenomewide association scangenomewide association studygenomic toolsgenomic variantglobal gene expressionglobal transcription profilehelicasehuman exposureiPSiPSCiPSCsindividuals on the autism spectrumindividuals on the spectrumindividuals with ASDindividuals with autismindividuals with autism spectrum disorderinduced pluripotent cellinduced pluripotent stem cellinducible pluripotent cellinducible pluripotent stem cellinherited factorinterestloss of function mutationlow-frequency mutationmalemouse mutantnecropsynerve stem cellneural precursorneural precursor cellneural progenitorneural progenitor cellsneural stem and progenitor cellsneurodevelopmentneurodevelopmental diseaseneurogenic progenitorsneurogenic stem cellneuron progenitorsneuronal progenitorneuronal progenitor cellsneuronal stem cellsneuroprogenitornoncodingnoveloverexpressoverexpressionpatch clamppathwaypatient subclasspatient subclusterpatient subgroupspatient subpopulationspatient subsetspatient subtypespeople on the autism spectrumpeople with ASDpeople with autismpeople with autism spectrum disorderpostmortemprogenitor and neural stem cellsprogramsrare allelerare mutationrare variantrepetitive behaviorresponserisk allelerisk generisk genotyperisk locirisk locusrisk variantscRNA sequencingscRNA-seqsexsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocialsocial communicationsynapsetranscriptional silencingtranscriptomewhole genome association analysiswhole genome association study♀♂
Description preview
Project Description
Autism spectrum disorder (ASD) is a highly prevalent neurodevelopmental disorder characterized by social
communication deficits and repetitive behaviors with restricted interests. The lifelong social and behavioral
challenges, along with a lack of therapeutic agents designed to treat core symptoms, places ASD as a
significant…
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