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Epigenetic and genetic regulation of arsenic methylation and arsenic-relatedcardiovascular disease risk
Organization STANFORD UNIVERSITYLocation STANFORD, UNITED STATESPosted 1 Apr 2024Deadline 31 Mar 2026 ⚠️
NIHUS FederalResearch GrantFY202521+ years oldAdultAdult HumanApplied SkillsArsenicArsenic CompoundsArsenicalsBioinformaticsBiologic FactorBiologicalBiological FactorsBiological MarkersBiometricsBiometryBiostatisticsCardiovascularCardiovascular Body SystemCardiovascular DiseasesCardiovascular Organ SystemCardiovascular systemCausalityCell Communication and SignalingCell SignalingCluster AnalysesCluster AnalysisCohort StudiesComplexConcurrent StudiesDNA MethylationDNA Methylation RegulationDataDevelopmentDiseaseDisease OutcomeDisorderEWASEnvironmental EpidemiologyEnvironmental FactorEnvironmental Risk FactorEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEthnic GroupEthnic PeopleEthnic PopulationEthnic individualEthnicity PeopleEthnicity PopulationEtiologyExcretory functionFaceFamily StudyFoundationsGene TranscriptionGenesGeneticGenetic DiversityGenetic TranscriptionGenetic VariationHealthHeartHeart VascularHepaticIncidenceIndividualIngestionIntracellular Communication and SignalingInvestigatorsLinkMachine LearningMeasuresMediatingMediationMediatorMentorshipMessenger RNAMethodsMethylationMicroRNAsMolecularMolecular EpidemiologyMorbidityMorbidity - disease rateMultiomic DataNative AmericanNative American communityNative American groupNative American individualNative American peopleNative American populationNative AmericansNegotiatingNegotiationNetwork AnalysisOutcomePathway AnalysisPathway interactionsPhasePhenotypePopulationPost-Transcriptional ControlPost-Transcriptional RegulationPrivatizationProcessPublic HealthQTLQuantitative Trait LociRNA ExpressionRegulationResearchResearch PersonnelResearchersRiskRoleSignal TransductionSignal Transduction SystemsSignalingTestingToxic effectToxicitiesToxinTrainingTranscriptionUnited StatesUrineWorkadulthoodanthropogenesisanthropogenicarsenicalarsenicsbio-markersbiologicbiologic markerbiological signal transductionbiomarkerbiomarker developmentbiomarker validationburden of chronic diseaseburden of chronic illnesscandidate identificationcarcinogenicitycardiovascular disease riskcardiovascular disordercardiovascular disorder riskcardiovascular riskcardiovascular risk factorcareercareer developmentcausationcirculating miRNAcirculating microRNAcirculatory systemcohortdevelopmentaldisease causationdisease riskdisorder riskdrinking waterenvironmental riskepigenetic biomarkerepigenetic markerepigenetic regulationepigeneticallyepigenome wide association analysisepigenome-wide association studiesethnic subgroupethnicity groupexcretionfacesfacialgene interactiongenetic epidemiologic studygenetic epidemiologyhigh dimensionalityingestinsightmRNAmachine based learningmachine learning based methodmachine learning methodmachine learning methodologiesmarker validationmethylation biomarkermethylation markermiRNAmiRNA biomarkersmiRNA markersmicroRNA biomarkersmicroRNA markersmortalitymultiomicsmultiple omic datamultiple omicspanomicspathwaypost-transcriptional gene regulationposttranscriptionalprospectivepublic health interventionrecruitrural Americansrural dwellingrural householdsrural residencesocial roleurinary
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SUMMARY
In the United States, Native American communities face the greatest burden of chronic diseases among all ethnic
groups and high rates of cardiovascular disease (CVD) incidence and mortality. Elevated disease risk may be in
part attributed to arsenic in drinking water, which is a key environmental risk factor among rural households that…
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