grant
Epigenetic age acceleration and differences among immune cell populations in people with and without HIV
Organization VANDERBILT UNIVERSITY MEDICAL CENTERLocation NASHVILLE, UNITED STATESPosted 15 May 2026Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY202621+ years old5 year old5 years of ageAIDS VirusAccelerationAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAddressAdultAdult HumanAffectAgeAgingAssayAutomobile DrivingB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBioassayBiologic ModelsBiologicalBiological AssayBiological FunctionBiological MarkersBiological ModelsBiological ProcessBiologyBiology of AgingBlood SampleBlood monocyteBlood specimenBody TissuesCD8CD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCD8BCD8B1CD8B1 geneCardiovascular DiseasesCell AgingCell BodyCell SenescenceCell divisionCellsCellular AgingCellular SenescenceCessation of lifeChronologyClinicalClinical ResearchClinical StudyCognitiveCognitive DisturbanceCognitive ImpairmentCognitive agingCognitive declineCognitive function abnormalComplexCryofixationCryopreservationCytotoxic cellDNA DamageDNA InjuryDNA MethylationDNA methylation profilingDataData SetDeathDiseaseDisorderDisturbance in cognitionElderlyEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEpigenetic ageEvaluationExhibitsFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFutureGenomeGenomicsGeroscienceGoalsGrimAge clockHIVHIV InfectionsHIV and agingHIV associated agingHIV individualsHIV infected individualsHIV infected personsHIV peopleHIV positive individualsHIV positive peopleHIV related agingHIV viral infectionHIV virus infectionHIV-1 infectionHannum clockHorvath clockHuman Immunodeficiency VirusesHybrid captureHybridization captureImmuneImmune Cell ActivationImmune systemImmunesImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsImmunologyImpaired cognitionIndividualInfection by HIV-1Infection from HIV-1Infection of HIV-1InflammationInstitutionInterventionInvestigationInvestigatorsIxodidaK lymphocyteLAV-HTLV-IIILYT3Life StyleLifestyleLymphadenopathy-Associated VirusMarrow monocyteMeasuresMemoryMethodsMethyl-SeqMethylSeqMethylationMethylation sequencingModel SystemMorbidityNK CellsNational Institutes of HealthNatural Killer CellsObesityObservational StudyOutcomePBMCPLWHPWHPatternPerformancePeripheral Blood Mononuclear CellPersonsPhenoAge clocksPhysical FunctionPhysiologicPhysiologicalPopulationReplicative SenescenceReproducibilityResearch PersonnelResearch ResourcesResearchersResourcesRiskRisk AssessmentSamplingSenotherapeuticSiteSmokingSortingSyndromeT memory cellT-Cell SubsetsT-CellsT-LymphocyteT-Lymphocyte SubsetsT8 CellsT8 LymphocytesTestingTicksTissuesUnited States National Institutes of HealthVariantVariationVirus-HIVWhole BloodWorkaccelerated agingaccelerated biological ageaccelerated biological agingaccelerated epigenetic ageaccelerated epigenetic agingaccelerated pace of epigenetic agingacceleration in epigenetic ageadiposityadult youthadulthoodadvanced ageage 5age 5 yearsage accelerationage associatedage associated alterationsage associated changesage associated differenceage based differenceage correlatedage correlated alterationsage correlated changesage dependentage dependent alterationsage dependent changesage dependent differenceage dependent variationage differenceage induced alterationsage induced changesage linkedage relatedage related alterationsage related changesage related differenceage related pathwaysage related variationage specificage specific alterationsage specific changesage specific differenceagesaging associatedaging associated alterationsaging associated changesaging associated mechanismaging correlated alterationsaging correlated changesaging dependent alterationsaging dependent changesaging induced alterationsaging induced changesaging mechanismaging pathwayaging people with HIVaging population with HIVaging processaging relatedaging related alterationsaging related changesaging related mechanismaging related pathwaysaging specific alterationsaging specific changesaging with HIVaging with human immunodeficiency virusalterations with ageantiretroviral therapyantiretroviral treatmentbio-markersbiologicbiologic markerbiological agebiological mechanism of agebiological pathways of agebiomarkercardiovascular disordercell typechanges with ageclinical epidemiologyclinical predictorsclinical riskco-morbidco-morbiditycognitive dysfunctioncognitive functioncognitive losscognitive performancecold preservationcold storagecomorbiditycorpulencecostcost effectivedecline in functiondecline in functional statusdiffer by agedifference across agedifference in agedrivingearly onsetepigenetic age clocksepigenetic clockepigenetic molecular clocksepigeneticallyepigenomeepigenomicsexhaustionexperiencefaster epigenetic agingfaster rates of epigenetic agingfive year oldfive years of ageflow cytophotometryfrailtyfunctional declinefunctional status declinegenome scalegenome sciencesgenome-widegenomewidegenomic sciencegeriatricgeroscientifichigh riskhuman immunodeficiency virus infectionhybridization-based captureimmune activationimmune senescenceimmunosenescenceimprovedincreased epigenetic ageincreased epigenetic agingincreased rates of epigenetic agingindividuals infected with HIVindividuals with HIVindividuals with human immunodeficiency virusinfected with HIVinfected with human immunodeficiency virusinnovateinnovationinnovativeinsightmechanism regulating agingmechanisms involved in agingmemory T lymphocytemethylation clockmethylation patternminiaturizeminiaturizedmonocytemortalitymultidisciplinarynovelobservational research studyobservational surveyolder adultolder adulthoodpathway involved in agingpeople infected with HIVpeople infected with human immunodeficiency viruspeople living with HIVpeople with HIVpeople with human immunodeficiency virusphenotypic datapredict clinical outcomeprospectivepublic health prioritiespublic health relevancequantification of agingrapid epigenetic agingrepairrepairedreplicative agingsenescencesenescentsenior citizensystemic inflammationsystemic inflammatory responsethymus derived lymphocytetoolvariation by ageyoung adultyoung adult ageyoung adulthoodyounger age
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Project Summary / Abstract
With effects on multiple cellular mechanisms of aging – including systemic inflammation, cellular senescence,
and DNA damage – HIV infection is a recognized biological model of age acceleration. Indeed, people living
with HIV (PWH) experience higher risk and earlier onset of a number of aging-related conditions,…
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