grant
EPHB2-Dependent Signaling: A New Molecular Paradigm in Barrett's Neoplasia
Organization CASE WESTERN RESERVE UNIVERSITYLocation CLEVELAND, UNITED STATESPosted 20 Sept 2023Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DAccelerationAdenocarcinoma of the EsophagusAnimal ModelAnimal Models and Related StudiesBarrett EsophagusBarrett SyndromeBarrett UlcerBarrett's carcinogenesisBarrett's neoplasiaBasal Transcription FactorBasal transcription factor genesBeta Proprotein Interleukin 1Bile AcidsBindingBinding ProteinsBiologicalBiological MarkersBiopsyBody TissuesCancer InductionCancersCausalityCell BodyCell Communication and SignalingCell LineCell LineageCell SignalingCellLineCellsChemopreventiveChemopreventive AgentColumnar Epithelial-Lined Lower EsophagusColumnar-Lined EsophagusComplexCoupledDevelopmentDiseaseDisease ProgressionDisorderDistalDysplasiaE3 LigaseE3 Ubiquitin LigaseEPHB2EPHB2 geneEPHT3EPTH3Efbn2 Gene ProductEphrin-B2EpitheliumEplg5 Gene ProductEplg5 ProteinEsophageal AdenocarcinomaEsophageal Squamous CellEsophageal injuryEsophageal mucous membraneEsophagusEtiologyExposure toFamily suidaeGastroenterologyGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenetic TranscriptionGlandGoalsHek5HereditaryHumanIL-1 betaIL-1 βIL-1-bIL-1βIL1-BetaIL1-βIL1B ProteinIL1F2IL1βImmunoglobulin Enhancer-Binding ProteinIn SituIn VitroInflammationInflammatoryInheritedInjuryInjury to EsophagusInterleukin 1betaInterleukin-1 betaInterleukin-1βIntestinalIntestinesIntracellular Communication and SignalingKinasesLERK-5 Gene ProductLERK-5 ProteinLesionLigand Binding ProteinLigand Binding Protein GeneLinkMalignantMalignant - descriptorMalignant NeoplasmsMalignant TumorMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMediatingMetaplasiaMetaplastic ChangeMiceMice MammalsModelingModern ManMolecularMolecular InteractionMucosaMucosal TissueMucous MembraneMurineMusNF-kBNF-kappa BNF-kappaBNFKBNeoplasmsNetwork AnalysisNuclear Factor kappa BNuclear Transcription Factor NF-kBOrganoidsPTK ReceptorsPathogenesisPathologicPathway AnalysisPathway interactionsPatientsPhenotypePhosphorylationPhosphotransferase GenePhosphotransferasesPigsPredispositionPreinterleukin 1 BetaProgenitor CellsProtein BindingProtein PhosphorylationRNA ExpressionRNA SeqRNA sequencingRNAseqReceptor Protein-Tyrosine KinasesReceptor Tyrosine Kinase GeneRefluxRegulationRiskRisk FactorsRodent ModelRoleSignal TransductionSignal Transduction SystemsSignalingSourceStrains Cell LinesSubmucosaSuidaeSusceptibilitySwineTYRO5TestingTherapeuticTimeTissuesTranscriptionTranscription Factor NF-kBTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional ControlTranscriptional RegulationTransitional CellTransmembrane Receptor Protein Tyrosine KinaseTransphosphorylasesTyrosine Kinase Linked ReceptorsTyrosine Kinase ReceptorsUbiquitin Protein LigaseUbiquitin-Protein Ligase ComplexesUbiquitin-Protein Ligase E3United StatesWound Repairanti-carcinogenicbio-markersbiologicbiologic markerbiological signal transductionbiomarkerbound proteinbowelc mycc-myc Genescancer preventioncarcinogenesiscausationchemoprevention agentclinical implementationcmyccultured cell linedesigndesigningdevelopmentaldisease causationdyscrasiaesophageal intestinal metaplasiaesophageal mucosaesophageal progenitorsesophageal squamous epithelial cellesophageal stem cellevidence basegenome scalegenome-widegenomewidein vivoinjuriesinjury and repairkappa B Enhancer Binding Proteinmalignancymodel of animalmolecular shapemouse modelmurine modelneoplasianeoplasm/cancerneoplastic growthnovelnuclear factor kappa betapathwayphospho-proteomicsphosphoproteomicsporcinepre-clinical studypreclinical studyprecursor cellprogramspromoterpromotorscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsstem cellssuidsynergismthree dimensionaltranscription factortranscriptome sequencingtranscriptomic sequencingtumor growthubiquitin-protein ligasev-myc Avian Myelocytomatosis Viral Oncogene Cellular Homologwound healingwound recoverywound resolution
Description preview
PROJECT SUMMARY/ABSTRACT
The etiology of Barrett's esophagus (BE), a molecularly complex disorder of the distal esophagus, remains
elusive. Patients with BE are at an increased risk of developing esophageal adenocarcinoma (EAC), a lethal,
increasingly prevalent, and the most common esophageal malignancy in the U.S. Our long-term objective is to…
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